Collateral Damage from Antigen Receptor Gene Diversification

Chromosomal translocations that juxtapose antigen receptor genes and oncogenes are frequently associated with lymphoid malignancies. In this issue, Robbiani et al. (2008) show that activation-induced deaminase (AID), an enzyme involved in antigen receptor gene diversification, generates DNA double-s...

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Bibliographic Details
Published in:Cell 2008-12, Vol.135 (6), p.1009-1012
Main Authors: Mahowald, Grace K., Baron, Jason M., Sleckman, Barry P.
Format: Article
Language:English
Subjects:
Animals
Cytidine Deaminase - metabolism
DNA Breaks, Double-Stranded
DNA Repair
Homeodomain Proteins - metabolism
Humans
Lymphoma - genetics
Lymphoma - metabolism
Receptors, Antigen - genetics
Receptors, Antigen - metabolism
Translocation, Genetic
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Summary:Chromosomal translocations that juxtapose antigen receptor genes and oncogenes are frequently associated with lymphoid malignancies. In this issue, Robbiani et al. (2008) show that activation-induced deaminase (AID), an enzyme involved in antigen receptor gene diversification, generates DNA double-strand breaks (DSBs) in oncogenes, and Tsai et al. (2008) propose that AID and the recombinase-activating gene (RAG) endonuclease may collaborate to generate off-target DSBs.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2008.11.024