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Ewing’s sarcoma of the head and neck in children

Objective: The purpose of this paper was to review our experience with Ewing’s sarcoma of the head and neck in children. Design: Retrospective chart review. Setting: The Hospital for Sick Children, Toronto, Ont., Canada. Methods: Between 1986 and 1996, 70 cases of Ewing’s sarcoma were identified. Th...

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Published in:International journal of pediatric otorhinolaryngology 1999-05, Vol.48 (3), p.209-216
Main Authors: Vaccani, J.P., Forte, V., de Jong, A.L., Taylor, G.
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container_title International journal of pediatric otorhinolaryngology
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creator Vaccani, J.P.
Forte, V.
de Jong, A.L.
Taylor, G.
description Objective: The purpose of this paper was to review our experience with Ewing’s sarcoma of the head and neck in children. Design: Retrospective chart review. Setting: The Hospital for Sick Children, Toronto, Ont., Canada. Methods: Between 1986 and 1996, 70 cases of Ewing’s sarcoma were identified. The medical records, roentgenographic and pathology reports were reviewed retrospectively. The gender, age of presentation, location and clinical presentation of the tumor were noted in the cases involving the head and neck. The treatment and follow-up of these patients were recorded. Results: Of the 70 cases of Ewing’s, five involved the head and neck (7.1%). The age of presentation ranged from 7.5 to 14 years. An enlarging mass in the mandible was the mode of presentation in three of the five children. Two patients had metastases at initial presentation. All patients received combination treatment regimens with chemotherapy initially, followed by adjuvant surgery and/or radiation. Follow-up ranged from 2 to 11 years. Three of five patients died of metastatic disease. Two are alive and well with no evidence of disease. Conclusions: Ewing’s sarcoma occurs infrequently in the head and neck in children. An enlarging mass in the mandible is the most frequent mode of presentation. This tumor is treated systemically with high dose chemotherapy and locally with surgical excision where possible. In lesions that are initially unresectable and/or show a poor response to chemotherapy, radiation is used for local control. A good prognosis can be expected if the disease has not metastasized.
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Design: Retrospective chart review. Setting: The Hospital for Sick Children, Toronto, Ont., Canada. Methods: Between 1986 and 1996, 70 cases of Ewing’s sarcoma were identified. The medical records, roentgenographic and pathology reports were reviewed retrospectively. The gender, age of presentation, location and clinical presentation of the tumor were noted in the cases involving the head and neck. The treatment and follow-up of these patients were recorded. Results: Of the 70 cases of Ewing’s, five involved the head and neck (7.1%). The age of presentation ranged from 7.5 to 14 years. An enlarging mass in the mandible was the mode of presentation in three of the five children. Two patients had metastases at initial presentation. All patients received combination treatment regimens with chemotherapy initially, followed by adjuvant surgery and/or radiation. Follow-up ranged from 2 to 11 years. Three of five patients died of metastatic disease. Two are alive and well with no evidence of disease. Conclusions: Ewing’s sarcoma occurs infrequently in the head and neck in children. An enlarging mass in the mandible is the most frequent mode of presentation. This tumor is treated systemically with high dose chemotherapy and locally with surgical excision where possible. In lesions that are initially unresectable and/or show a poor response to chemotherapy, radiation is used for local control. A good prognosis can be expected if the disease has not metastasized.</description><identifier>ISSN: 0165-5876</identifier><identifier>EISSN: 1872-8464</identifier><identifier>DOI: 10.1016/S0165-5876(99)00030-0</identifier><identifier>PMID: 10402117</identifier><identifier>CODEN: IPOTDJ</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Biological and medical sciences ; Child ; Children ; Combined Modality Therapy ; Ewing’s sarcoma ; Female ; Head and neck ; Head and Neck Neoplasms - diagnostic imaging ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - therapy ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Osteoarticular system. Muscles ; Prognosis ; Radiodiagnosis. Nmr imagery. 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Design: Retrospective chart review. Setting: The Hospital for Sick Children, Toronto, Ont., Canada. Methods: Between 1986 and 1996, 70 cases of Ewing’s sarcoma were identified. The medical records, roentgenographic and pathology reports were reviewed retrospectively. The gender, age of presentation, location and clinical presentation of the tumor were noted in the cases involving the head and neck. The treatment and follow-up of these patients were recorded. Results: Of the 70 cases of Ewing’s, five involved the head and neck (7.1%). The age of presentation ranged from 7.5 to 14 years. An enlarging mass in the mandible was the mode of presentation in three of the five children. Two patients had metastases at initial presentation. All patients received combination treatment regimens with chemotherapy initially, followed by adjuvant surgery and/or radiation. Follow-up ranged from 2 to 11 years. Three of five patients died of metastatic disease. Two are alive and well with no evidence of disease. Conclusions: Ewing’s sarcoma occurs infrequently in the head and neck in children. An enlarging mass in the mandible is the most frequent mode of presentation. This tumor is treated systemically with high dose chemotherapy and locally with surgical excision where possible. In lesions that are initially unresectable and/or show a poor response to chemotherapy, radiation is used for local control. A good prognosis can be expected if the disease has not metastasized.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Children</subject><subject>Combined Modality Therapy</subject><subject>Ewing’s sarcoma</subject><subject>Female</subject><subject>Head and neck</subject><subject>Head and Neck Neoplasms - diagnostic imaging</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Osteoarticular system. Muscles</subject><subject>Prognosis</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Retrospective Studies</subject><subject>Sarcoma, Ewing - diagnostic imaging</subject><subject>Sarcoma, Ewing - pathology</subject><subject>Sarcoma, Ewing - therapy</subject><subject>Tomography, X-Ray Computed</subject><issn>0165-5876</issn><issn>1872-8464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkMtOwzAQRS0EoqXwCaAsEIJFYJzEjrNCqCoPqRILYG059oQa8ih2CmLHb_B7fAlpUwE7NjObc2euDiH7FE4pUH521w0WMpHy4yw7AYAYQtggQyrSKBQJTzbJ8AcZkB3vnwBoCoxtkwGFBCJK0yGJJm-2fvz6-PSBV043lQqaImhnGMxQmUDVJqhRPwe2DvTMlsZhvUu2ClV63FvvEXm4nNyPr8Pp7dXN-GIa6oTxNmQYmzgVyBKMIIooFyrTlEcFzXMGKheR5nmSIBhtCsUEzQ1PC5UbGsdppmg8Ikf93blrXhboW1lZr7EsVY3NwkueCSGyhHcg60HtGu8dFnLubKXcu6Qgl7LkSpZcmpBZJleyJHS5g_WDRV6h-ZPq7XTA4RpQXquycKrW1v9yIhYClkXPeww7G68WnfTaYq3RWIe6laax_zT5BrbzhQY</recordid><startdate>19990525</startdate><enddate>19990525</enddate><creator>Vaccani, J.P.</creator><creator>Forte, V.</creator><creator>de Jong, A.L.</creator><creator>Taylor, G.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>19990525</creationdate><title>Ewing’s sarcoma of the head and neck in children</title><author>Vaccani, J.P. ; Forte, V. ; de Jong, A.L. ; Taylor, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-5e3d378e54e2022168a9c162f1bb50ab82c6b44e0dcdfa581bd67fabd13379a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Children</topic><topic>Combined Modality Therapy</topic><topic>Ewing’s sarcoma</topic><topic>Female</topic><topic>Head and neck</topic><topic>Head and Neck Neoplasms - diagnostic imaging</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Osteoarticular system. Muscles</topic><topic>Prognosis</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Retrospective Studies</topic><topic>Sarcoma, Ewing - diagnostic imaging</topic><topic>Sarcoma, Ewing - pathology</topic><topic>Sarcoma, Ewing - therapy</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaccani, J.P.</creatorcontrib><creatorcontrib>Forte, V.</creatorcontrib><creatorcontrib>de Jong, A.L.</creatorcontrib><creatorcontrib>Taylor, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>International journal of pediatric otorhinolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaccani, J.P.</au><au>Forte, V.</au><au>de Jong, A.L.</au><au>Taylor, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ewing’s sarcoma of the head and neck in children</atitle><jtitle>International journal of pediatric otorhinolaryngology</jtitle><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><date>1999-05-25</date><risdate>1999</risdate><volume>48</volume><issue>3</issue><spage>209</spage><epage>216</epage><pages>209-216</pages><issn>0165-5876</issn><eissn>1872-8464</eissn><coden>IPOTDJ</coden><abstract>Objective: The purpose of this paper was to review our experience with Ewing’s sarcoma of the head and neck in children. 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Two are alive and well with no evidence of disease. Conclusions: Ewing’s sarcoma occurs infrequently in the head and neck in children. An enlarging mass in the mandible is the most frequent mode of presentation. This tumor is treated systemically with high dose chemotherapy and locally with surgical excision where possible. In lesions that are initially unresectable and/or show a poor response to chemotherapy, radiation is used for local control. A good prognosis can be expected if the disease has not metastasized.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>10402117</pmid><doi>10.1016/S0165-5876(99)00030-0</doi><tpages>8</tpages></addata></record>
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ispartof International journal of pediatric otorhinolaryngology, 1999-05, Vol.48 (3), p.209-216
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subjects Adolescent
Biological and medical sciences
Child
Children
Combined Modality Therapy
Ewing’s sarcoma
Female
Head and neck
Head and Neck Neoplasms - diagnostic imaging
Head and Neck Neoplasms - pathology
Head and Neck Neoplasms - therapy
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Osteoarticular system. Muscles
Prognosis
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Retrospective Studies
Sarcoma, Ewing - diagnostic imaging
Sarcoma, Ewing - pathology
Sarcoma, Ewing - therapy
Tomography, X-Ray Computed
title Ewing’s sarcoma of the head and neck in children
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