Evidence for Linkage Between Essential Hypertension and a Putative Locus on Human Chromosome 17

Several clinical and animal studies indicate that essential hypertension is inherited as a multifactorial trait with a significant genetic and environmental component. In the stroke-prone spontaneously hypertensive rat model, investigators have found evidence for linkage to blood pressure regulatory...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-07, Vol.34 (1), p.4-7
Main Authors: Baima, Jader, Nicolaou, Michael, Schwartz, Faina, DeStefano, Anita L, Manolis, Athanasios, Gavras, Irene, Laffer, Cheryl, Elijovich, Fernando, Farrer, Lindsay, Baldwin, Clinton T, Gavras, Haralambos
Format: Article
Language:English
Subjects:
African Continental Ancestry Group - genetics
Aged
Alleles
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - genetics
Body Mass Index
Cardiology. Vascular system
Chromosome Mapping
Chromosomes, Human, Pair 17 - genetics
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Cohort Studies
European Continental Ancestry Group - genetics
Gene Frequency
Genetic Linkage - genetics
Humans
Hypertension - ethnology
Hypertension - genetics
Hypertension - pathology
Medical sciences
Microsatellite Repeats - genetics
Middle Aged
Obesity - genetics
Quantitative Trait, Heritable
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Summary:Several clinical and animal studies indicate that essential hypertension is inherited as a multifactorial trait with a significant genetic and environmental component. In the stroke-prone spontaneously hypertensive rat model, investigators have found evidence for linkage to blood pressure regulatory genes (quantitative trait loci) on rat chromosomes 2, 10, and X. In 1 human study of French and UK sib pairs, evidence for linkage has been reported to human chromosome 17q, the syntenic region of the rat chromosome 10 quantitative trait loci (QTL). Our study confirms this linkage (P=0.0005) and refines the location of the blood pressure QTL. (Hypertension. 1999;34:4-7.)
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.34.1.4