Endometrial sonographic characters predicting pregnancy following recurrent clomiphene induction in unexplained infertility

Abstract Patients with unexplained infertility managed repeatedly with clomiphene citrate need parameters to predict pregnancy to save them further unsuccessful trials and shorten their treatment to pregnancy interval. Ovulation was induced in 226 unexplained infertility patients, who had three prev...

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Bibliographic Details
Published in:Reproductive biomedicine online 2008, Vol.17 (6), p.795-802
Main Author: Shahin, Ahmed Y
Format: Article
Language:English
Subjects:
Adult
Chorionic Gonadotropin - metabolism
clomiphene
Clomiphene - pharmacology
endometrial echogenicity
endometrium
Endometrium - diagnostic imaging
Endometrium - drug effects
Endometrium - pathology
Female
Fertility Agents, Female - pharmacology
Humans
Infertility, Female - drug therapy
Obstetrics and Gynecology
Ovulation
Ovulation Induction - methods
Pregnancy
Progesterone - metabolism
ROC Curve
Sensitivity and Specificity
Ultrasonography - methods
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Summary:Abstract Patients with unexplained infertility managed repeatedly with clomiphene citrate need parameters to predict pregnancy to save them further unsuccessful trials and shorten their treatment to pregnancy interval. Ovulation was induced in 226 unexplained infertility patients, who had three previous failed cycles, with 100 mg clomiphene citrate (CC) from days 3 to 7 of the cycle. Human chorionic gonadotrophin (HCG) injection (10,000 IU i.m.) was given and timed intercourse was recommended when a leading follicle reached >17 mm and serum oestradiol exceeded 200 pg/ml. A receiver operating characteristic (ROC) curve showed that endometrial thickness >11.60 mm was associated with the lowest, while values >5.50 mm were associated with the highest chance of pregnancy. An endometrial thickness of 7.05 mm showed the best sensitivity and specificity. Patients with endometrial thickness
ISSN:1472-6483
1472-6491
DOI:10.1016/S1472-6483(10)60407-5