Nucleated red blood cells as a marker of acidemia in term neonates

Objectives: Nucleated red blood cells are produced in increased numbers under hypoxic conditions. We sought to examine the relationship between nucleated red blood cell count in the circulations of term neonates and other possible markers of fetal hypoxia. Study Design: We prospectively collected um...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 1999-07, Vol.181 (1), p.196-201
Main Authors: Hanlon-Lundberg, Kathleen M., Kirby, Russell S.
Format: Article
Language:English
Subjects:
Acidosis - diagnosis
Apgar Score
Biological and medical sciences
Biomarkers
Blood Gas Analysis
Delivery. Postpartum. Lactation
Erythrocyte Count
Erythrocytes - metabolism
Female
Fetal acidemia
Fetal Diseases - diagnosis
fetal hypoxia
Fetal Hypoxia - diagnosis
Gynecology. Andrology. Obstetrics
Humans
Hydrogen-Ion Concentration
Infant, Newborn - blood
Maternal, fetal and perinatal monitoring
Medical Records
Medical sciences
nucleated red blood cells
Pregnancy
Prospective Studies
Retrospective Studies
umbilical arterial blood gas values
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Summary:Objectives: Nucleated red blood cells are produced in increased numbers under hypoxic conditions. We sought to examine the relationship between nucleated red blood cell count in the circulations of term neonates and other possible markers of fetal hypoxia. Study Design: We prospectively collected umbilical blood from all live-born neonates delivered at our institution. Arterial blood was analyzed for pH and blood gas values. Venous blood was analyzed for nucleated red blood cell count. We reviewed the medical records for maternal data and neonatal outcomes of gestations of ≥37 weeks’ duration. Results: We evaluated 1561 cases. The mean nucleated red blood cell count per 100 white blood cells was 9.2 ± 18.1 (range, 0-327). Nucleated red blood cell counts were higher in infants with pH
ISSN:0002-9378
1097-6868
DOI:10.1016/S0002-9378(99)70459-X