Antiparasitic, nematicidal and antifouling constituents from Juniperus berries

A bioassay-guided fractionation of Juniperus procera berries yielded antiparasitic, nematicidal and antifouling constituents, including a wide range of known abietane, pimarane and labdane diterpenes. Among these, abieta-7,13-diene (1) demonstrated in vitro antimalarial activity against Plasmodium f...

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Bibliographic Details
Published in:Phytotherapy research 2008-12, Vol.22 (12), p.1570-1576
Main Authors: Samoylenko, Volodymyr, Dunbar, D. Chuck, Gafur, Md. Abdul, Khan, Shabana I, Ross, Samir A, Mossa, Jaber S, El-Feraly, Farouk S, Tekwani, Babu L, Bosselaers, Jan, Muhammad, Ilias
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
antifouling
Antinematodal Agents - pharmacology
antiparasitic
Antiprotozoal Agents - pharmacology
Artemia - drug effects
Biological and medical sciences
Caenorhabditis elegans - drug effects
diterpenes
Diterpenes - pharmacology
Diterpenes, Abietane - pharmacology
Fruit - chemistry
Gas Chromatography-Mass Spectrometry
General pharmacology
J. excelsa
J. phoenicea
J. virginiana
Juniperus - chemistry
Juniperus procera
Leishmania donovani - drug effects
Medical sciences
Microbial Sensitivity Tests
nematicidal
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plasmodium falciparum - drug effects
Resins, Plant - chemistry
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Summary:A bioassay-guided fractionation of Juniperus procera berries yielded antiparasitic, nematicidal and antifouling constituents, including a wide range of known abietane, pimarane and labdane diterpenes. Among these, abieta-7,13-diene (1) demonstrated in vitro antimalarial activity against Plasmodium falciparum D6 and W2 strains (IC₅₀ = 1.9 and 2.0 μg/mL, respectively), while totarol (6), ferruginol (7) and 7β-hydroxyabieta-8,13-diene-11,12-dione (8) inhibited Leishmania donovani promastigotes with IC₅₀ values of 3.5-4.6 μg/mL. In addition, totarol demonstrated nematicidal and antifouling activities against Caenorhabditis elegans and Artemia salina at a concentration of 80 μg/mL and 1 μg/mL, respectively. The resinous exudate of J. virginiana afforded known antibacterial E-communic acid (4) and 4-epi-abietic acid (5), while the volatile oil from its trunk wood revealed large quantities of cedrol (9). Using GC/MS, the two known abietanes totarol (6) and ferruginol (7) were identified from the berries of J. procera, J. excelsa and J. phoenicea. Copyright © 2008 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.2460