Correlation Between IL-10 Gene Expression and HPV Infection in Cervical Cancer: A Mechanism for Immune Response Escape

The present study was performed to determine IL-10 expression in cervical tissues in Mexican women according to the severity of the malignity and its association with HPV infection. IL-10 expression showed a clear tendency to increase during the different cervical cancer stages: 37% in LGSIL; 62% in...

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Bibliographic Details
Published in:Cancer investigation 2008-01, Vol.26 (10), p.1037-1043
Main Authors: Bermúdez-Morales, Victor H., Gutiérrez, Lourdes X., Alcocer-González, Juan M., Burguete, Ana, Madrid-Marina, Vicente
Format: Article
Language:English
Subjects:
Cervical cancer
DNA Primers
DNA, Neoplasm - genetics
DNA, Neoplasm - isolation & purification
Female
Gene Expression Regulation, Neoplastic
HPV
Humans
IL-10
Immunosuppression
Interleukin-10 - genetics
Mexico
Neoplasm Staging
Papillomavirus Infections - complications
Papillomavirus Infections - epidemiology
Papillomavirus Infections - immunology
Prevalence
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Neoplasm - genetics
RNA, Neoplasm - isolation & purification
Uterine Cervical Neoplasms - complications
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - immunology
Uterine Cervical Neoplasms - pathology
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Summary:The present study was performed to determine IL-10 expression in cervical tissues in Mexican women according to the severity of the malignity and its association with HPV infection. IL-10 expression showed a clear tendency to increase during the different cervical cancer stages: 37% in LGSIL; 62% in HGSIL; and 84% in cancer. However, all the patients that expressed IL-10 were HPV positives; we found an association with HPV 16. These results suggest a clear relationship between IL-10, HPV and the stage of cervical cancer disease; this event could contribute to the immunosuppressive micro-environment in the tumor site.
ISSN:0735-7907
1532-4192
DOI:10.1080/07357900802112693