Effects of estrogen and estrogen-progesteron on serum nitric oxide metabolite concentrations in post-menopausal women

Estrogens have some anti-atherosclerotic properties and they influence nitric oxide (NO) production. The aim of this study was to determine NOx levels in post-menopausal women and the effect of estrogen/estrogen-progesteron therapy (ET/EPT) on plasma NO levels. Eighty postmenopausal women (M1) compr...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2008-10, Vol.31 (10), p.877-881
Main Authors: Bednarek-Tupikowska, G., Tworowska-Bardzińska, U., Tupikowski, K.
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Endocrinology
Estradiol - administration & dosage
Estrogen Replacement Therapy
Female
Humans
Lipoproteins - blood
Medicine
Medicine & Public Health
Medroxyprogesterone Acetate - administration & dosage
Metabolic Diseases
Middle Aged
Nitric Oxide - blood
Nitrogen Oxides - blood
Original Article
Postmenopause - blood
Premenopause - blood
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Summary:Estrogens have some anti-atherosclerotic properties and they influence nitric oxide (NO) production. The aim of this study was to determine NOx levels in post-menopausal women and the effect of estrogen/estrogen-progesteron therapy (ET/EPT) on plasma NO levels. Eighty postmenopausal women (M1) comprising 26 with surgically induced menopause (ET1), mean age 50.9+/-2.9 yr, and 54 with physiological menopause (EPT1), mean age 50.5+/-3.0 yr, were studied. Forty healthy pre-menopausal women, mean age 48.3+/-2.3 yr were the controls (C). The post-menopausal women were treated for 4 months: group ET1 with ET and group EPT1 with EPT. Serum estradiol (E2), FSH, NOx and lipid profile before and after therapy were measured. NOx levels were lower in group M1 than in group C (8.75+/-1.57 vs 10.27+/-2.62, p
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03346435