Enhanced sympathetic and ventilatory responses to central chemoreflex activation in heart failure

Sympathetic activation and respiratory abnormalities may each be implicated in the pathophysiology of congestive heart failure (CHF). Chemoreflexes are an important mechanism regulating both sympathetic drive and breathing. We therefore tested the hypothesis that chemoreflex function is altered in C...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1999-07, Vol.100 (3), p.262-267
Main Authors: NARKIEWICZ, K, PESEK, C. A, VAN DE BORNE, P. J. H, KATO, M, SOMERS, V. K
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cardiology. Vascular system
Cold Temperature
Female
Heart
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hemodynamics
Humans
Hypercapnia - physiopathology
Hypoxia - physiopathology
Male
Medical sciences
Reflex
Respiration
Sympathetic Nervous System - physiology
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Summary:Sympathetic activation and respiratory abnormalities may each be implicated in the pathophysiology of congestive heart failure (CHF). Chemoreflexes are an important mechanism regulating both sympathetic drive and breathing. We therefore tested the hypothesis that chemoreflex function is altered in CHF. We compared ventilatory, sympathetic, heart rate, and blood pressure responses to hypoxia, hypercapnia, and the cold pressor test in 9 patients with CHF and 9 control subjects matched for age and body mass index. Baseline muscle sympathetic nerve activity (MSNA) was higher in the patients with CHF compared with control subjects (47+/-8 versus 23+/-3 bursts per minute, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.100.3.262