Early rheumatoid arthritis is associated with diminished numbers of TH1 cells in stimulated peripheral blood

Rheumatoid arthritis (RA) has been associated with an altered TH1/TH2 balance. Here we present first results with a technique to quantitate stimulated TH1 and TH2 subsets in whole blood by means of cytofluorimetric detection of intracytoplasmic TH1 and TH2 cytokines. A group of 10 patients suffering...

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Bibliographic Details
Published in:Immunobiology (1979) 1999-06, Vol.200 (2), p.290-294
Main Authors: Mangge, H, Felsner, P, Herrmann, J, el-Shabrawi, Y, Liebmann, P, Schauenstein, K
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
AIDS/HIV
Arthritis, Rheumatoid - immunology
CD3 Complex - immunology
Female
Humans
Leukocytes, Mononuclear - immunology
Male
Middle Aged
Th1 Cells - immunology
Th2 Cells - immunology
Time Factors
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Summary:Rheumatoid arthritis (RA) has been associated with an altered TH1/TH2 balance. Here we present first results with a technique to quantitate stimulated TH1 and TH2 subsets in whole blood by means of cytofluorimetric detection of intracytoplasmic TH1 and TH2 cytokines. A group of 10 patients suffering from initial stages of RA exhibited a significantly reduced percentage of TH1 cells (11.0 +/- 2.0%) in the peripheral blood as compared to 13 healthy, age matched controls (28.8 +/- 2.0%). The TH2 response, as determined by intracellular expression of IL-4, remained unchanged. The data may indicate a defect in the TH0-TH1 differentiation or/and a selective trapping of TH1 cells into the affected joints.
ISSN:0171-2985
DOI:10.1016/S0171-2985(99)80077-1