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Prognostic Value of Lymphoma-specific S-Phase Fraction Compared with that of Other Cell Proliferation Markers

The proliferation-associated antigens Ki67 (immunohistochemistry) and proliferative cell nuclear antigen (PCNA) (immunohistochemistry and immunoblotting) were analysed together with DNA synthesis (3H-thymidine incorporation) and cell-cycle distribution (tumour-specific S-phase fraction determined by...

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Bibliographic Details
Published in:Acta oncologica 1999, Vol.38 (4), p.495-503
Main Author: Harald Holte, Zhenhe Suo, Erlend B. Smeland, Stein Kvaløy, Ruth Langholm, Trond Stokke
Format: Article
Language:English
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Summary:The proliferation-associated antigens Ki67 (immunohistochemistry) and proliferative cell nuclear antigen (PCNA) (immunohistochemistry and immunoblotting) were analysed together with DNA synthesis (3H-thymidine incorporation) and cell-cycle distribution (tumour-specific S-phase fraction determined by flow cytometry) in lymph node suspensions from 63 patients with newly diagnosed B-Cell non-Hodgkin's lymphomas. Details of clinical parameters, treatment and patient outcome were available for all patients, and retrospectively analysed. Of the proliferation-associated parameters, only high S-phase fraction (p
ISSN:0284-186X
1651-226X
DOI:10.1080/028418699432040