Long-term immunotherapy for perennial allergic rhinitis: relationship of specific IgG levels to skin-prick test results and clinical symptoms and signs

We studied 63 adults with perennial allergic rhinitis and positive skin-prick tests for Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farinae (Df) who had not previously received any type of immunotherapy or pharmacotherapy for their condition. We injected these patients with a 50% Dp/50%...

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Bibliographic Details
Published in:Ear, nose, & throat journal nose, & throat journal, 2008-12, Vol.87 (12), p.E29-E29
Main Authors: Tahamiler, Rauf, Canakcioglu, Salih, Yilmaz, Suleyman, Isildak, Huseyin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Dermatophagoides pteronyssinus - immunology
Female
Humans
Immunoglobulin G - immunology
Immunotherapy - methods
Male
Middle Aged
Rhinitis, Allergic, Perennial - immunology
Rhinitis, Allergic, Perennial - therapy
Skin Tests
Time Factors
Young Adult
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Summary:We studied 63 adults with perennial allergic rhinitis and positive skin-prick tests for Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farinae (Df) who had not previously received any type of immunotherapy or pharmacotherapy for their condition. We injected these patients with a 50% Dp/50% Df modified allergen intradermally in accordance with the classic immunotherapy scheme once a week for 30 months. Specific immunotherapy (SIT) was administered until the specific IgG (sIgG) concentration reached level IV (>or=81% absorbance). We measured specific IgE and sIgG levels, obtained skin-prick test results, and evaluated clinical symptoms and signs before immunotherapy, at 6 months into therapy, at the completion of therapy (30 mo), and 1 year after the completion of therapy. In the group as a whole, differences between mean sIgG values and mean skin-prick test results before and after SIT were statistically significant (p < 0.05). At the 1-year follow-up, there was a negative correlation between sIgG levels and clinical symptom and sign scores, a positive correlation between skin-prick test results and clinical improvement, and a negative correlation between sIgG levels and skin-prick test results. Individually, at the 1-year follow-up, 50 of the 63 patients (79%) had experienced a resolution of clinical symptoms and/or signs and were thus deemed to have achieved clinical recovery.
ISSN:1942-7522