Genetic admixture and diversity estimations in the Mexican Mestizo population from Mexico City using 15 STR polymorphic markers

Abstract The 15 AmpFlSTR Identifiler loci D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA were analyzed in a sample of 378 unrelated individuals from Mexico City, Mexico. Significant deviations from HW equilibrium in 14/15 STR loc...

Full description

Saved in:
Bibliographic Details
Published in:Forensic science international : genetics 2008-06, Vol.2 (3), p.e37-e39
Main Authors: Juárez-Cedillo, Teresa, Zuñiga, Joaquín, Acuña-Alonzo, Victor, Pérez-Hernández, Nonanzit, Rodríguez-Pérez, José Manuel, Barquera, Rodrigo, Gallardo, Guillermo J, Sánchez-Arenas, Rosalinda, García-Peña, Maria del Carmen, Granados, Julio, Vargas-Alarcón, Gilberto
Format: Article
Language:English
Subjects:
African Continental Ancestry Group - genetics
African Continental Ancestry Group - statistics & numerical data
Alleles
Analysis of Variance
DNA Fingerprinting - methods
European Continental Ancestry Group - genetics
European Continental Ancestry Group - statistics & numerical data
Gene Frequency
Genetic Markers
Genetic Variation
Genetics, Population
Genotype
Humans
Indians, North American - genetics
Indians, North American - statistics & numerical data
Mexico
Microsatellite Repeats - genetics
Pathology
Polymorphism, Genetic
Quality Control
Reference Standards
Urban Population
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The 15 AmpFlSTR Identifiler loci D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA were analyzed in a sample of 378 unrelated individuals from Mexico City, Mexico. Significant deviations from HW equilibrium in 14/15 STR loci alleles were not detected. The D18S51 locus had the highest power of discrimination (0.970). Genetic admixture estimations revealed a 69% of Amerindian, 26% of European and 5% of African contribution. Comparative analyses between Mexicans and other neighboring populations reveal significant differences in genetic diversity. Our results are important for future comparative genetic studies in different Latin American ethnic groups, particularly Mexican Mestizos and Amerindians. They should also be helpful in genetics, population evolution, forensic and paternity testing.
ISSN:1872-4973
1878-0326
DOI:10.1016/j.fsigen.2007.08.017