Inhibition of cathepsin D by tripeptides containing statine analogs

Various analogs of statine, a remarkable amino acid component of the protease inhibitor pepstatine, were synthesized and evaluated as tripeptide derivatives for their activity against cathepsin D and HIV-1 protease.

Saved in:
Bibliographic Details
Published in:Biochemical pharmacology 1999-07, Vol.58 (2), p.329-333
Main Authors: Bessodes, Michel, Antonakis, Kostas, Herscovici, Jean, Garcia, Marcel, Rochefort, Henri, Capony, Françoise, Lelièvre, Yves, Scherman, Daniel
Format: Article
Language:English
Subjects:
AIDS/HIV
Amino Acids - chemistry
Amino Acids - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antineoplastic agents
Antiviral agents
Biological and medical sciences
cathepsin D
Cathepsin D - antagonists & inhibitors
cell proliferation
General aspects
HIV Protease Inhibitors - chemistry
HIV Protease Inhibitors - pharmacology
Humans
inhibitor
Medical sciences
Oligopeptides - chemistry
Oligopeptides - pharmacology
Pepstatins - chemistry
Pharmacology. Drug treatments
protease
Protease Inhibitors - chemistry
Protease Inhibitors - pharmacology
statine
Structure-Activity Relationship
tripeptide
Tumor Cells, Cultured
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Various analogs of statine, a remarkable amino acid component of the protease inhibitor pepstatine, were synthesized and evaluated as tripeptide derivatives for their activity against cathepsin D and HIV-1 protease.
ISSN:0006-2952
1873-2968
DOI:10.1016/S0006-2952(99)00103-3