Ainsliatrimers A and B, the First Two Guaianolide Trimers from Ainsliaea fulvioides

Ainsliatrimers A (1) and B (2), the first two guaianolide-type sesquiterpene lactone trimers, together with one new structurally related sesquiterpene dimer ainsliadimer B (3), were isolated from the aerial part of Ainsliaea fulvioides. Their structures were elucidated by spectroscopic techniques, i...

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Published in:Organic letters 2008-12, Vol.10 (24), p.5517-5520
Main Authors: Wang, Yan, Shen, Yun-Heng, Jin, Hui-Zi, Fu, Jian-Jun, Hu, Xiao-Jia, Qin, Jiang-Jiang, Liu, Jian-Hua, Chen, Ming, Yan, Shi-Kai, Zhang, Wei-Dong
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Asteraceae - chemistry
Asteraceae - metabolism
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Molecular Conformation
Plant Components, Aerial - chemistry
Plant Components, Aerial - metabolism
Sesquiterpenes, Guaiane - chemistry
Sesquiterpenes, Guaiane - isolation & purification
Sesquiterpenes, Guaiane - pharmacology
X-Ray Diffraction
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Summary:Ainsliatrimers A (1) and B (2), the first two guaianolide-type sesquiterpene lactone trimers, together with one new structurally related sesquiterpene dimer ainsliadimer B (3), were isolated from the aerial part of Ainsliaea fulvioides. Their structures were elucidated by spectroscopic techniques, including X-ray crystal diffraction. Both 1 and 2 showed potent cytotoxicites against LOVO and CEM cell lines.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol802249z