Peptoid architectures: elaboration, actuation, and application

Peptoids are peptidomimetic oligomers composed of N-substituted glycine units. Their convenient synthesis enables strict control over the sequence of highly diverse monomers and is capable of generating extensive compound libraries. Recent studies are beginning to explore the relationship between pe...

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Bibliographic Details
Published in:Current opinion in chemical biology 2008-12, Vol.12 (6), p.714-721
Main Authors: Yoo, Barney, Kirshenbaum, Kent
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Drug Design
Peptoids - chemical synthesis
Peptoids - chemistry
Peptoids - metabolism
Protein Structure, Secondary
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Summary:Peptoids are peptidomimetic oligomers composed of N-substituted glycine units. Their convenient synthesis enables strict control over the sequence of highly diverse monomers and is capable of generating extensive compound libraries. Recent studies are beginning to explore the relationship between peptoid sequence, structure and function. We describe new approaches to direct the conformation of the peptoid backbone, leading to secondary structures such as helices, loops, and turns. These advances are enabling the discovery of bioactive peptoids and will establish modules for the design and assembly of protein mimetics.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2008.08.015