Loading…

Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells

The effects of mitogen-activated protein (MAP) kinase inhibitors or phosphodiesterase (PDE) inhibitors on interleukin (IL)-1-induced cytokines production in synovium-derived cells were investigated. Human synoviocyte (HS) or synovial sarcoma (SW982) stimulated by IL-1β (100 ng/ml) produced various c...

Full description

Saved in:
Bibliographic Details
Published in:Immunology letters 1999-06, Vol.68 (2), p.275-279
Main Authors: Tsuji, Fumio, Oki, Kenji, Senda, Toshihiko, Horiuchi, Masato, Mita, Shiro
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c413t-1e11810d4aa0b72c2eb92019a1a9ab98801021b42e84e6d3ebf7e940fb4b7ba13
cites cdi_FETCH-LOGICAL-c413t-1e11810d4aa0b72c2eb92019a1a9ab98801021b42e84e6d3ebf7e940fb4b7ba13
container_end_page 279
container_issue 2
container_start_page 275
container_title Immunology letters
container_volume 68
creator Tsuji, Fumio
Oki, Kenji
Senda, Toshihiko
Horiuchi, Masato
Mita, Shiro
description The effects of mitogen-activated protein (MAP) kinase inhibitors or phosphodiesterase (PDE) inhibitors on interleukin (IL)-1-induced cytokines production in synovium-derived cells were investigated. Human synoviocyte (HS) or synovial sarcoma (SW982) stimulated by IL-1β (100 ng/ml) produced various cytokines including IL-6, IL-8, GROα, VEGF, basic FGF and tumor necrosis factor α (TNFα) in vitro. SB202190 or SB203580, an inhibitor of p38 MAP kinase, inhibited all cytokines production in both cells. PD98059, an inhibitor of MAP kinase kinase (MEK), inhibited IL-6, IL-8 and basic FGF production in HS and all cytokines production except basic FGF in SW982. However, many of its effects were weaker than those of SB202190 or SB203580. Quazinone, an inhibitor of cyclic GMP-inhibited PDE, scarcely affected cytokines production in both cells. Rolipram or RO201724, an inhibitor of cyclic AMP-specific PDE, inhibited IL-8 and basic FGF production in HS and TNFα production in SW982, however, it enhanced the other cytokines production in SW982. These results suggest that the activation of MAP kinase cascade may be important for IL-1-induced cytokines production in synovium-derived cells. On the other hand, the role of cyclic AMP may be dependent on cell and cytokine types.
doi_str_mv 10.1016/S0165-2478(99)00051-6
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69920086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165247899000516</els_id><sourcerecordid>69920086</sourcerecordid><originalsourceid>FETCH-LOGICAL-c413t-1e11810d4aa0b72c2eb92019a1a9ab98801021b42e84e6d3ebf7e940fb4b7ba13</originalsourceid><addsrcrecordid>eNqFkU2PFCEQhonRuOPqT9D0yeiBlaLpD07GbNaPZJM9rJ4JdFe76DSMQE8yf8bfavXMxhgvewBC8dRbVbyMvQRxAQLad7e0NVyqrn-j9VshRAO8fcQ20Heai0bJx2zzFzljz3L-IQQ0taqfsjMQSipVyw37fTVNOJRcxamafYnfMXA7FL-3Bcdql2JBH6qfPtiMlQ933hGUCE_V7i5mWqPHXDD9_x7oRuEtLpTMgfswLgNJDocSKYJ5FadQ8Ue0yocQ936Z-YjJ71cQt9v8nD2Z7Dbji_vznH37ePX18jO_vvn05fLDNR8U1IUDAvQgRmWtcJ0cJDotBWgLVlun-16AkOCUxF5hO9bopg61EpNTrnMW6nP2-qRLTf1aaCAz-7x2YAPGJZtWk57oWwKbEzikmHPCyeySn206GBBmNcYcjTHrrxutzdEYs-a9ui-wuBnHf7JOThDw_gQgjbn3mEwePAb6Mp_IIDNG_0CJP7Aqoo0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69920086</pqid></control><display><type>article</type><title>Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells</title><source>ScienceDirect Journals</source><creator>Tsuji, Fumio ; Oki, Kenji ; Senda, Toshihiko ; Horiuchi, Masato ; Mita, Shiro</creator><creatorcontrib>Tsuji, Fumio ; Oki, Kenji ; Senda, Toshihiko ; Horiuchi, Masato ; Mita, Shiro</creatorcontrib><description>The effects of mitogen-activated protein (MAP) kinase inhibitors or phosphodiesterase (PDE) inhibitors on interleukin (IL)-1-induced cytokines production in synovium-derived cells were investigated. Human synoviocyte (HS) or synovial sarcoma (SW982) stimulated by IL-1β (100 ng/ml) produced various cytokines including IL-6, IL-8, GROα, VEGF, basic FGF and tumor necrosis factor α (TNFα) in vitro. SB202190 or SB203580, an inhibitor of p38 MAP kinase, inhibited all cytokines production in both cells. PD98059, an inhibitor of MAP kinase kinase (MEK), inhibited IL-6, IL-8 and basic FGF production in HS and all cytokines production except basic FGF in SW982. However, many of its effects were weaker than those of SB202190 or SB203580. Quazinone, an inhibitor of cyclic GMP-inhibited PDE, scarcely affected cytokines production in both cells. Rolipram or RO201724, an inhibitor of cyclic AMP-specific PDE, inhibited IL-8 and basic FGF production in HS and TNFα production in SW982, however, it enhanced the other cytokines production in SW982. These results suggest that the activation of MAP kinase cascade may be important for IL-1-induced cytokines production in synovium-derived cells. On the other hand, the role of cyclic AMP may be dependent on cell and cytokine types.</description><identifier>ISSN: 0165-2478</identifier><identifier>EISSN: 1879-0542</identifier><identifier>DOI: 10.1016/S0165-2478(99)00051-6</identifier><identifier>PMID: 10424432</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology ; Calcium-Calmodulin-Dependent Protein Kinases - antagonists &amp; inhibitors ; Cytokine ; Cytokines - biosynthesis ; Dose-Response Relationship, Drug ; Humans ; Imidazoles - pharmacology ; Interleukin-1 - pharmacology ; Mitogen-activated protein kinase inhibitor ; Phosphodiesterase inhibitor ; Phosphodiesterase Inhibitors - pharmacology ; Pyridines - pharmacology ; Pyrrolidinones - pharmacology ; Quinazolines - pharmacology ; Rolipram ; Synovial Membrane - cytology ; Synovial Membrane - drug effects ; Synovial Membrane - immunology ; Synovium</subject><ispartof>Immunology letters, 1999-06, Vol.68 (2), p.275-279</ispartof><rights>1999 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-1e11810d4aa0b72c2eb92019a1a9ab98801021b42e84e6d3ebf7e940fb4b7ba13</citedby><cites>FETCH-LOGICAL-c413t-1e11810d4aa0b72c2eb92019a1a9ab98801021b42e84e6d3ebf7e940fb4b7ba13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10424432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsuji, Fumio</creatorcontrib><creatorcontrib>Oki, Kenji</creatorcontrib><creatorcontrib>Senda, Toshihiko</creatorcontrib><creatorcontrib>Horiuchi, Masato</creatorcontrib><creatorcontrib>Mita, Shiro</creatorcontrib><title>Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells</title><title>Immunology letters</title><addtitle>Immunol Lett</addtitle><description>The effects of mitogen-activated protein (MAP) kinase inhibitors or phosphodiesterase (PDE) inhibitors on interleukin (IL)-1-induced cytokines production in synovium-derived cells were investigated. Human synoviocyte (HS) or synovial sarcoma (SW982) stimulated by IL-1β (100 ng/ml) produced various cytokines including IL-6, IL-8, GROα, VEGF, basic FGF and tumor necrosis factor α (TNFα) in vitro. SB202190 or SB203580, an inhibitor of p38 MAP kinase, inhibited all cytokines production in both cells. PD98059, an inhibitor of MAP kinase kinase (MEK), inhibited IL-6, IL-8 and basic FGF production in HS and all cytokines production except basic FGF in SW982. However, many of its effects were weaker than those of SB202190 or SB203580. Quazinone, an inhibitor of cyclic GMP-inhibited PDE, scarcely affected cytokines production in both cells. Rolipram or RO201724, an inhibitor of cyclic AMP-specific PDE, inhibited IL-8 and basic FGF production in HS and TNFα production in SW982, however, it enhanced the other cytokines production in SW982. These results suggest that the activation of MAP kinase cascade may be important for IL-1-induced cytokines production in synovium-derived cells. On the other hand, the role of cyclic AMP may be dependent on cell and cytokine types.</description><subject>4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases - antagonists &amp; inhibitors</subject><subject>Cytokine</subject><subject>Cytokines - biosynthesis</subject><subject>Dose-Response Relationship, Drug</subject><subject>Humans</subject><subject>Imidazoles - pharmacology</subject><subject>Interleukin-1 - pharmacology</subject><subject>Mitogen-activated protein kinase inhibitor</subject><subject>Phosphodiesterase inhibitor</subject><subject>Phosphodiesterase Inhibitors - pharmacology</subject><subject>Pyridines - pharmacology</subject><subject>Pyrrolidinones - pharmacology</subject><subject>Quinazolines - pharmacology</subject><subject>Rolipram</subject><subject>Synovial Membrane - cytology</subject><subject>Synovial Membrane - drug effects</subject><subject>Synovial Membrane - immunology</subject><subject>Synovium</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkU2PFCEQhonRuOPqT9D0yeiBlaLpD07GbNaPZJM9rJ4JdFe76DSMQE8yf8bfavXMxhgvewBC8dRbVbyMvQRxAQLad7e0NVyqrn-j9VshRAO8fcQ20Heai0bJx2zzFzljz3L-IQQ0taqfsjMQSipVyw37fTVNOJRcxamafYnfMXA7FL-3Bcdql2JBH6qfPtiMlQ933hGUCE_V7i5mWqPHXDD9_x7oRuEtLpTMgfswLgNJDocSKYJ5FadQ8Ue0yocQ936Z-YjJ71cQt9v8nD2Z7Dbji_vznH37ePX18jO_vvn05fLDNR8U1IUDAvQgRmWtcJ0cJDotBWgLVlun-16AkOCUxF5hO9bopg61EpNTrnMW6nP2-qRLTf1aaCAz-7x2YAPGJZtWk57oWwKbEzikmHPCyeySn206GBBmNcYcjTHrrxutzdEYs-a9ui-wuBnHf7JOThDw_gQgjbn3mEwePAb6Mp_IIDNG_0CJP7Aqoo0</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>Tsuji, Fumio</creator><creator>Oki, Kenji</creator><creator>Senda, Toshihiko</creator><creator>Horiuchi, Masato</creator><creator>Mita, Shiro</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells</title><author>Tsuji, Fumio ; Oki, Kenji ; Senda, Toshihiko ; Horiuchi, Masato ; Mita, Shiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-1e11810d4aa0b72c2eb92019a1a9ab98801021b42e84e6d3ebf7e940fb4b7ba13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases - antagonists &amp; inhibitors</topic><topic>Cytokine</topic><topic>Cytokines - biosynthesis</topic><topic>Dose-Response Relationship, Drug</topic><topic>Humans</topic><topic>Imidazoles - pharmacology</topic><topic>Interleukin-1 - pharmacology</topic><topic>Mitogen-activated protein kinase inhibitor</topic><topic>Phosphodiesterase inhibitor</topic><topic>Phosphodiesterase Inhibitors - pharmacology</topic><topic>Pyridines - pharmacology</topic><topic>Pyrrolidinones - pharmacology</topic><topic>Quinazolines - pharmacology</topic><topic>Rolipram</topic><topic>Synovial Membrane - cytology</topic><topic>Synovial Membrane - drug effects</topic><topic>Synovial Membrane - immunology</topic><topic>Synovium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuji, Fumio</creatorcontrib><creatorcontrib>Oki, Kenji</creatorcontrib><creatorcontrib>Senda, Toshihiko</creatorcontrib><creatorcontrib>Horiuchi, Masato</creatorcontrib><creatorcontrib>Mita, Shiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsuji, Fumio</au><au>Oki, Kenji</au><au>Senda, Toshihiko</au><au>Horiuchi, Masato</au><au>Mita, Shiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells</atitle><jtitle>Immunology letters</jtitle><addtitle>Immunol Lett</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>68</volume><issue>2</issue><spage>275</spage><epage>279</epage><pages>275-279</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><abstract>The effects of mitogen-activated protein (MAP) kinase inhibitors or phosphodiesterase (PDE) inhibitors on interleukin (IL)-1-induced cytokines production in synovium-derived cells were investigated. Human synoviocyte (HS) or synovial sarcoma (SW982) stimulated by IL-1β (100 ng/ml) produced various cytokines including IL-6, IL-8, GROα, VEGF, basic FGF and tumor necrosis factor α (TNFα) in vitro. SB202190 or SB203580, an inhibitor of p38 MAP kinase, inhibited all cytokines production in both cells. PD98059, an inhibitor of MAP kinase kinase (MEK), inhibited IL-6, IL-8 and basic FGF production in HS and all cytokines production except basic FGF in SW982. However, many of its effects were weaker than those of SB202190 or SB203580. Quazinone, an inhibitor of cyclic GMP-inhibited PDE, scarcely affected cytokines production in both cells. Rolipram or RO201724, an inhibitor of cyclic AMP-specific PDE, inhibited IL-8 and basic FGF production in HS and TNFα production in SW982, however, it enhanced the other cytokines production in SW982. These results suggest that the activation of MAP kinase cascade may be important for IL-1-induced cytokines production in synovium-derived cells. On the other hand, the role of cyclic AMP may be dependent on cell and cytokine types.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>10424432</pmid><doi>10.1016/S0165-2478(99)00051-6</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0165-2478
ispartof Immunology letters, 1999-06, Vol.68 (2), p.275-279
issn 0165-2478
1879-0542
language eng
recordid cdi_proquest_miscellaneous_69920086
source ScienceDirect Journals
subjects 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology
Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors
Cytokine
Cytokines - biosynthesis
Dose-Response Relationship, Drug
Humans
Imidazoles - pharmacology
Interleukin-1 - pharmacology
Mitogen-activated protein kinase inhibitor
Phosphodiesterase inhibitor
Phosphodiesterase Inhibitors - pharmacology
Pyridines - pharmacology
Pyrrolidinones - pharmacology
Quinazolines - pharmacology
Rolipram
Synovial Membrane - cytology
Synovial Membrane - drug effects
Synovial Membrane - immunology
Synovium
title Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T07%3A19%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20mitogen-activated%20protein%20kinase%20inhibitors%20or%20phosphodiesterase%20inhibitors%20on%20interleukin-1-induced%20cytokines%20production%20in%20synovium-derived%20cells&rft.jtitle=Immunology%20letters&rft.au=Tsuji,%20Fumio&rft.date=1999-06-01&rft.volume=68&rft.issue=2&rft.spage=275&rft.epage=279&rft.pages=275-279&rft.issn=0165-2478&rft.eissn=1879-0542&rft_id=info:doi/10.1016/S0165-2478(99)00051-6&rft_dat=%3Cproquest_cross%3E69920086%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c413t-1e11810d4aa0b72c2eb92019a1a9ab98801021b42e84e6d3ebf7e940fb4b7ba13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=69920086&rft_id=info:pmid/10424432&rfr_iscdi=true