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Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells
The effects of mitogen-activated protein (MAP) kinase inhibitors or phosphodiesterase (PDE) inhibitors on interleukin (IL)-1-induced cytokines production in synovium-derived cells were investigated. Human synoviocyte (HS) or synovial sarcoma (SW982) stimulated by IL-1β (100 ng/ml) produced various c...
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Published in: | Immunology letters 1999-06, Vol.68 (2), p.275-279 |
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description | The effects of mitogen-activated protein (MAP) kinase inhibitors or phosphodiesterase (PDE) inhibitors on interleukin (IL)-1-induced cytokines production in synovium-derived cells were investigated. Human synoviocyte (HS) or synovial sarcoma (SW982) stimulated by IL-1β (100 ng/ml) produced various cytokines including IL-6, IL-8, GROα, VEGF, basic FGF and tumor necrosis factor α (TNFα) in vitro. SB202190 or SB203580, an inhibitor of p38 MAP kinase, inhibited all cytokines production in both cells. PD98059, an inhibitor of MAP kinase kinase (MEK), inhibited IL-6, IL-8 and basic FGF production in HS and all cytokines production except basic FGF in SW982. However, many of its effects were weaker than those of SB202190 or SB203580. Quazinone, an inhibitor of cyclic GMP-inhibited PDE, scarcely affected cytokines production in both cells. Rolipram or RO201724, an inhibitor of cyclic AMP-specific PDE, inhibited IL-8 and basic FGF production in HS and TNFα production in SW982, however, it enhanced the other cytokines production in SW982. These results suggest that the activation of MAP kinase cascade may be important for IL-1-induced cytokines production in synovium-derived cells. On the other hand, the role of cyclic AMP may be dependent on cell and cytokine types. |
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Human synoviocyte (HS) or synovial sarcoma (SW982) stimulated by IL-1β (100 ng/ml) produced various cytokines including IL-6, IL-8, GROα, VEGF, basic FGF and tumor necrosis factor α (TNFα) in vitro. SB202190 or SB203580, an inhibitor of p38 MAP kinase, inhibited all cytokines production in both cells. PD98059, an inhibitor of MAP kinase kinase (MEK), inhibited IL-6, IL-8 and basic FGF production in HS and all cytokines production except basic FGF in SW982. However, many of its effects were weaker than those of SB202190 or SB203580. Quazinone, an inhibitor of cyclic GMP-inhibited PDE, scarcely affected cytokines production in both cells. Rolipram or RO201724, an inhibitor of cyclic AMP-specific PDE, inhibited IL-8 and basic FGF production in HS and TNFα production in SW982, however, it enhanced the other cytokines production in SW982. These results suggest that the activation of MAP kinase cascade may be important for IL-1-induced cytokines production in synovium-derived cells. 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Human synoviocyte (HS) or synovial sarcoma (SW982) stimulated by IL-1β (100 ng/ml) produced various cytokines including IL-6, IL-8, GROα, VEGF, basic FGF and tumor necrosis factor α (TNFα) in vitro. SB202190 or SB203580, an inhibitor of p38 MAP kinase, inhibited all cytokines production in both cells. PD98059, an inhibitor of MAP kinase kinase (MEK), inhibited IL-6, IL-8 and basic FGF production in HS and all cytokines production except basic FGF in SW982. However, many of its effects were weaker than those of SB202190 or SB203580. Quazinone, an inhibitor of cyclic GMP-inhibited PDE, scarcely affected cytokines production in both cells. Rolipram or RO201724, an inhibitor of cyclic AMP-specific PDE, inhibited IL-8 and basic FGF production in HS and TNFα production in SW982, however, it enhanced the other cytokines production in SW982. These results suggest that the activation of MAP kinase cascade may be important for IL-1-induced cytokines production in synovium-derived cells. 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Oki, Kenji ; Senda, Toshihiko ; Horiuchi, Masato ; Mita, Shiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-1e11810d4aa0b72c2eb92019a1a9ab98801021b42e84e6d3ebf7e940fb4b7ba13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors</topic><topic>Cytokine</topic><topic>Cytokines - biosynthesis</topic><topic>Dose-Response Relationship, Drug</topic><topic>Humans</topic><topic>Imidazoles - pharmacology</topic><topic>Interleukin-1 - pharmacology</topic><topic>Mitogen-activated protein kinase inhibitor</topic><topic>Phosphodiesterase inhibitor</topic><topic>Phosphodiesterase Inhibitors - pharmacology</topic><topic>Pyridines - pharmacology</topic><topic>Pyrrolidinones - pharmacology</topic><topic>Quinazolines - pharmacology</topic><topic>Rolipram</topic><topic>Synovial Membrane - cytology</topic><topic>Synovial Membrane - drug effects</topic><topic>Synovial Membrane - immunology</topic><topic>Synovium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuji, Fumio</creatorcontrib><creatorcontrib>Oki, Kenji</creatorcontrib><creatorcontrib>Senda, Toshihiko</creatorcontrib><creatorcontrib>Horiuchi, Masato</creatorcontrib><creatorcontrib>Mita, Shiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsuji, Fumio</au><au>Oki, Kenji</au><au>Senda, Toshihiko</au><au>Horiuchi, Masato</au><au>Mita, Shiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells</atitle><jtitle>Immunology letters</jtitle><addtitle>Immunol Lett</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>68</volume><issue>2</issue><spage>275</spage><epage>279</epage><pages>275-279</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><abstract>The effects of mitogen-activated protein (MAP) kinase inhibitors or phosphodiesterase (PDE) inhibitors on interleukin (IL)-1-induced cytokines production in synovium-derived cells were investigated. Human synoviocyte (HS) or synovial sarcoma (SW982) stimulated by IL-1β (100 ng/ml) produced various cytokines including IL-6, IL-8, GROα, VEGF, basic FGF and tumor necrosis factor α (TNFα) in vitro. SB202190 or SB203580, an inhibitor of p38 MAP kinase, inhibited all cytokines production in both cells. PD98059, an inhibitor of MAP kinase kinase (MEK), inhibited IL-6, IL-8 and basic FGF production in HS and all cytokines production except basic FGF in SW982. However, many of its effects were weaker than those of SB202190 or SB203580. Quazinone, an inhibitor of cyclic GMP-inhibited PDE, scarcely affected cytokines production in both cells. Rolipram or RO201724, an inhibitor of cyclic AMP-specific PDE, inhibited IL-8 and basic FGF production in HS and TNFα production in SW982, however, it enhanced the other cytokines production in SW982. These results suggest that the activation of MAP kinase cascade may be important for IL-1-induced cytokines production in synovium-derived cells. 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subjects | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Cytokine Cytokines - biosynthesis Dose-Response Relationship, Drug Humans Imidazoles - pharmacology Interleukin-1 - pharmacology Mitogen-activated protein kinase inhibitor Phosphodiesterase inhibitor Phosphodiesterase Inhibitors - pharmacology Pyridines - pharmacology Pyrrolidinones - pharmacology Quinazolines - pharmacology Rolipram Synovial Membrane - cytology Synovial Membrane - drug effects Synovial Membrane - immunology Synovium |
title | Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells |
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