Comparison of visual microscopic and computer-automated fluorescence detection of rabies virus neutralizing antibodies

Institut Pasteur de Bruxelles, Service de la Rage, Belgium. The rapid fluorescent focus inhibition test (RFFIT) and the fluorescent antibody virus neutralization test (FAVNT) are both diagnostic tests for determining levels of rabies neutralizing antibodies. An automated method for determining fluor...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 1999-07, Vol.11 (4), p.330-333
Main Authors: Peharpre, D, Cliquet, F, Sagne, E, Renders, C, Costy, F, Aubert, M
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - blood
Autoanalysis - methods
Autoanalysis - veterinary
automation
detection
Dogs
fluorescence
Fluorescent Antibody Technique
Humans
microscopy
Microscopy, Fluorescence
Neutralization Tests
neutralizing antibodies
Rabies - blood
Rabies - diagnosis
Rabies - immunology
Rabies Vaccines
Rabies virus
Rabies virus - immunology
Regression Analysis
virus neutralization
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Summary:Institut Pasteur de Bruxelles, Service de la Rage, Belgium. The rapid fluorescent focus inhibition test (RFFIT) and the fluorescent antibody virus neutralization test (FAVNT) are both diagnostic tests for determining levels of rabies neutralizing antibodies. An automated method for determining fluorescence has been implemented to reduce the work time required for fluorescent visual microscopic observations. The automated method offers several advantages over conventional visual observation, such as the ability to rapidly test many samples. The antibody titers obtained with automated techniques were similar to those obtained with both the RFFIT (n = 165, r = 0.93, P
ISSN:1040-6387
1943-4936
DOI:10.1177/104063879901100406