Effect of liposomal tetracycline hydrochloride on enzymatic function of the liver

Preparation and physicochemical properties of liposome-incorporated tetracycline are described. Comparison of the effects of tetracycline hydrochloride in free and liposome-incorporated forms on enzymatic functions of the liver showed that immobilization of the antibiotic into liposomes protects liv...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-04, Vol.145 (4), p.443-445
Main Authors: Tikhonov, S. N, Rotov, K. A, Khrapova, N. P, Alekseev, V. V, Snatenkov, E. A, Zamarin, A. A, Simakova, N. A
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - metabolism
Alkaline Phosphatase - metabolism
Animals
Animals, Outbred Strains
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
antibiotics
Biomedical and Life Sciences
Biomedicine
Cell Biology
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Internal Medicine
Laboratory Medicine
liposomal form of tetracycline
Liposomes
Liver - drug effects
Liver - enzymology
liver enzymes
Liver Extracts - metabolism
Liver Function Tests
Mice
Pathology
Phosphorylases - metabolism
Tetracycline - administration & dosage
Tetracycline - pharmacology
Time Factors
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Summary:Preparation and physicochemical properties of liposome-incorporated tetracycline are described. Comparison of the effects of tetracycline hydrochloride in free and liposome-incorporated forms on enzymatic functions of the liver showed that immobilization of the antibiotic into liposomes protects liver cells from functional disturbances.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-008-0113-7