Specific adrenergic responses of smooth muscles in the vascular wall of guinea pig pulmonary arteries during ovalbumin sensitization

The adrenergic contractile responses of smooth muscles in the vascular wall of guinea pig pulmonary arteries were studied during ovalbumin sensitization. Sensitization was followed by inhibition of contractile responses to an α-adrenoceptor agonist mesatone, prevented endothelium-derived relaxation,...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-06, Vol.145 (6), p.673-675
Main Authors: Kapilevich, L. V., Nosarev, A. V., Djakova, E. Ju, Ogorodova, L. M., Zaitseva, T. N., Davletjarova, K. V., Kovalev, I. V., Baskakov, M. B., Sazonov, A. E., Medvedev, M. A.
Format: Article
Language:English
Subjects:
Adrenergic beta-Agonists - pharmacology
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Guinea Pigs
In Vitro Techniques
Internal Medicine
Isoproterenol - pharmacology
Isotonic Solutions - pharmacology
Laboratory Medicine
Muscle Contraction - drug effects
Muscle Relaxation - drug effects
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - immunology
Muscle, Smooth, Vascular - physiology
Ovalbumin - administration & dosage
Ovalbumin - immunology
Pathology
Pulmonary Artery - drug effects
Pulmonary Artery - physiology
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Summary:The adrenergic contractile responses of smooth muscles in the vascular wall of guinea pig pulmonary arteries were studied during ovalbumin sensitization. Sensitization was followed by inhibition of contractile responses to an α-adrenoceptor agonist mesatone, prevented endothelium-derived relaxation, and potentiated the contractile response to isoproterenol. Administration of a β-adrenoceptor agonist isoproterenol potentiated the increase in mechanical strain of smooth muscles in the pulmonary artery precontracted with high-potassium Krebs solution. Removal of the endothelium had no effect on the contractile response of smooth muscle segments from the pulmonary artery of intact and sensitized guinea pigs to β-adrenergic influences. The contractile responses of smooth muscles of the pulmonary artery are associated with activity of the cAMP-dependent signal system and play a role in the pathogenesis of ventilation-perfusion disturbances during atopic inflammation.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-008-0178-3