Reduction of hemorrhage after knee arthroplasty using cryo-based fibrin sealant

The spray application of cryo-based fibrin sealant was evaluated for reducing hemorrhage in a complex, anticoagulated canine model of knee joint arthroplasty. Nine heparinized dogs underwent bilateral knee arthroplasty under tourniquet control with each animal having 3 mL of fibrin sealant sprayed o...

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Bibliographic Details
Published in:The Journal of arthroplasty 1999-06, Vol.14 (4), p.481-487
Main Authors: Curtin, William A., Wang, Gwo J., Goodman, N.Craig, Abbott, Robert D., Spotnitz, William D.
Format: Article
Language:English
Subjects:
Animals
arthroplasty
Arthroplasty, Replacement, Knee
Dogs
Fibrin Tissue Adhesive
hemostasis
Hemostasis, Surgical - methods
Hindlimb
Humans
Postoperative Hemorrhage - prevention & control
Tissue Adhesives
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Summary:The spray application of cryo-based fibrin sealant was evaluated for reducing hemorrhage in a complex, anticoagulated canine model of knee joint arthroplasty. Nine heparinized dogs underwent bilateral knee arthroplasty under tourniquet control with each animal having 3 mL of fibrin sealant sprayed onto one joint and the other joint serving as control. The fibrin sealant significantly reduced total and incremental bleeding as compared to the control side ( P < .05). In addition, the hemostatic effectiveness of the fibrin sealant increased as bleeding propensity increased ( P < .05). This study suggests that fibrin sealant may reduce bleeding from orthopedic joint replacement in human patients undergoing routine operations as well as those receiving forms of anticoagulation to reduce the incidence of deep venous thrombosis and pulmonary embolus.
ISSN:0883-5403
1532-8406
DOI:10.1016/S0883-5403(99)90105-5