DNA mismatch repair deficiency in curatively resected sextuple primary cancers in different organs: a molecular case report

• Published in: Cancer letters 1999-07, Vol.142 (1), p.17-22
• Main Authors: Yakushiji, Hiroyuki, Mukai, Shinsuke, Matsukura, Shiroh, Sato, Seiji, Ogawa, Akiomi, Sasatomi, Eizaburo, Miyazaki, Kohji
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Aged; Base Pair Mismatch; BAX gene; Biological and medical sciences; Carcinoma - genetics; Carcinoma - pathology; Carcinoma - surgery; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - surgery; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Colonic Neoplasms - surgery; DNA mismatch repair deficiency; DNA Repair; DNA, Neoplasm - genetics; Humans; insulin-like growth factor II receptors; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Male; Medical sciences; Microsatellite instability; mismatch repair; Multiple primary cancers; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasms, Multiple Primary - genetics; Neoplasms, Multiple Primary - pathology; Neoplasms, Multiple Primary - surgery; Rectal Neoplasms - genetics; Rectal Neoplasms - pathology; Rectal Neoplasms - surgery; Replication error; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; transforming growth factor-^b receptors; Tumors; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - surgery
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/S0304-3835(99)00110-X

A male patient synchronously or metachronously underwent six curative resections after diagnoses of cancers in the rectum, urinary bladder, stomach, colon, liver and lung. Five cancers, excluding early colon cancer, were analyzed for instability in seven microsatellite markers and in transforming growth factor β type II receptor, insulin-like growth factor II receptor and BAX. All analyzed cancers had replication errors and instability in at least one target gene. These results suggest that abnormal DNA mismatch repair system plays a major role in the occurrence of multiple primary cancers in this case.