Determination of thiodiglycolic acid in urine by capillary electrophoresis

A sensitive capillary electrophoretic method was developed for the determination of thiodiglycolic acid (TDA) in urine which avoids the pretreatment of the urine sample. Several carrier electrolytes were examined. The most suitable carrier electrolyte system consisted of potassium hydrogen phthalate...

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Bibliographic Details
Published in:Journal of Chromatography A 1999-06, Vol.847 (1), p.135-139
Main Authors: Samcová, Eva, Kvasnicová, Vladimı́ra, Urban, Jiřı́, Jelı́nek, Ivan, Coufal, Pavel
Format: Article
Language:English
Subjects:
Biological and medical sciences
Buffers
Calibration
Chemical and industrial products toxicology. Toxic occupational diseases
Electrophoresis, Capillary - methods
Humans
Medical sciences
Spectrophotometry, Ultraviolet
Thiodiglycolic acid
Thioglycolates - urine
Toxicology
Various organic compounds
Vinyl chloride
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Summary:A sensitive capillary electrophoretic method was developed for the determination of thiodiglycolic acid (TDA) in urine which avoids the pretreatment of the urine sample. Several carrier electrolytes were examined. The most suitable carrier electrolyte system consisted of potassium hydrogen phthalate (5 m M), 2-( N-morpholino)ethanesulfonic acid (50 m M) and tetradecyltrimethylammonium bromide (0.5 m M), pH 5.2. Ten times diluted fresh midstream void urine was used for the determination. In this way, the concentrations of TDA between 5 and 50 mg/l in undiluted urine samples can be determined.
ISSN:0021-9673
DOI:10.1016/S0021-9673(98)01034-6