Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways

There is strong evidence that ductal carcinoma in situ (DCIS) represents a precursor lesion of invasive breast cancer. In order to analyse specific chromosomal alterations of DCIS, 38 paraffin‐embedded specimens of DCIS and six associated invasive carcinomas were examined by means of comparative gen...

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Bibliographic Details
Published in:The Journal of pathology 1999-03, Vol.187 (4), p.396-402
Main Authors: Buerger, Horst, Otterbach, Friedrich, Simon, Ronald, Poremba, Christopher, Diallo, Raihanatou, Decker, Thomas, Riethdorf, Lutz, Brinkschmidt, Christian, Dockhorn-Dworniczak, Barbara, Boecker, Werner
Format: Article
Language:English
Subjects:
Biological and medical sciences
breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Carcinoma in Situ - genetics
Carcinoma in Situ - pathology
Carcinoma, Ductal, Breast - genetics
Carcinoma, Ductal, Breast - pathology
Cell Differentiation
CGH
Chromosome Aberrations
Disease Progression
Female
Gynecology. Andrology. Obstetrics
Humans
in situ carcinoma
Male
Mammary gland diseases
Medical sciences
Neoplasm Invasiveness
Nucleic Acid Hybridization
Tumors
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Summary:There is strong evidence that ductal carcinoma in situ (DCIS) represents a precursor lesion of invasive breast cancer. In order to analyse specific chromosomal alterations of DCIS, 38 paraffin‐embedded specimens of DCIS and six associated invasive carcinomas were examined by means of comparative genomic hybridization (CGH). Losses of 16q material were seen almost exclusively in well‐ and intermediately‐differentiated DCIS. These two subgroups differed in the average number of genetic imbalances, 2·5 and 5·5 respectively. Additionally, a higher frequency of gains of 1q and losses of 11q material was seen in intermediately‐differentiated in contrast to well‐differentiated DCIS. Poorly‐differentiated DCIS displayed a higher frequency of amplifications (17q12, 11q13) and a higher average rate of genetic imbalances (7·1). Analysis of adjacent invasive breast carcinoma revealed a genetic pattern almost identical to the one seen in the DCIS counterpart. These data characterize DCIS as a genetically far‐advanced, heterogeneous lesion and as a direct precursor of invasive breast cancer. Copyright © 1999 John Wiley & Sons, Ltd.
ISSN:0022-3417
1096-9896
DOI:10.1002/(SICI)1096-9896(199903)187:4<396::AID-PATH286>3.0.CO;2-L