Evaluation of BCG Vaccine and Mycobacterium bovis Culture Filtrate Proteins against Bovine Tuberculosis

The objective of this study was to evaluate the degree of protection against TB of three immunogens in calves experimentally challenged with a pathogenic Mycobacterium bovis strain by identification of lesions during necropsy. Twenty‐four calves free of TB were distributed into four groups: group 1...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2008-12, Vol.1149 (1), p.306-308
Main Authors: Díaz-Otero, Fernando, Padilla, Jesus, Jaramillo, Laura, González, Dante, Arriaga, Camila
Format: Article
Language:English
Subjects:
Animals
BCG
BCG Vaccine - administration & dosage
bovine tuberculosis
Cattle
CFPE
dairy cattle
Filtration
immunogens
lesions
Mycobacterium bovis
Mycobacterium bovis - physiology
Tuberculosis, Bovine - prevention & control
vaccines
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Summary:The objective of this study was to evaluate the degree of protection against TB of three immunogens in calves experimentally challenged with a pathogenic Mycobacterium bovis strain by identification of lesions during necropsy. Twenty‐four calves free of TB were distributed into four groups: group 1 was inoculated with M. bovis CFPE, group 2 with CFPE/IFN‐γ, group 3 with M. bovis BCG, and group 4 remained as control. After 6 months all animals were challenged with an M. bovis field strain, and 6 months later the animals were euthanized and the presence of lesions was evaluated. Several degrees of protection were observed in the vaccinated groups, particularly in the group vaccinated with BCG, as shown by the absence or decrease in severity of lesions. Vaccination could be useful in high‐prevalence zones where it is economically unfeasible to slaughter animals.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1196/annals.1428.014