Estrogen Replacement Suppresses Pressor Response and Oxidative Stress Induced by Cage-switch Stress in Ovariectomized Rats

We examined the suppressive effects of estradiol on psychological stress–induced cardiovascular responses and oxidative stress in ovariectomized rats, both placebo‐treated (OVX+Pla) and estrogen‐treated (OVX+E2). The elevations in blood pressure and heart rate induced by cage‐switch stress were atte...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2008-12, Vol.1148 (1), p.213-218
Main Authors: Morimoto, Keiko, Uji, Masami, Ueyama, Takashi, Kimura, Hiroko, Kohno, Tomomi, Takamata, Akira, Yano, Shigenobu, Yoshida, Ken-Ichi
Format: Article
Language:English
Subjects:
Animals
blood pressure
Blood Pressure - drug effects
Blood Pressure - physiology
Enzyme Inhibitors - pharmacology
estradiol
Estrogen Replacement Therapy
Estrogens - pharmacology
Estrogens - therapeutic use
Female
heart rate
Housing, Animal
NG-Nitroarginine Methyl Ester - pharmacology
nitric oxide
Nitric Oxide - metabolism
ovariectomized rat
Ovariectomy
oxidative stress
Oxidative Stress - drug effects
Placebos
psychological stress
radiotelemetry
Random Allocation
Rats
Rats, Wistar
Stress, Psychological - drug therapy
Tyrosine - analogs & derivatives
Tyrosine - blood
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Summary:We examined the suppressive effects of estradiol on psychological stress–induced cardiovascular responses and oxidative stress in ovariectomized rats, both placebo‐treated (OVX+Pla) and estrogen‐treated (OVX+E2). The elevations in blood pressure and heart rate induced by cage‐switch stress were attenuated in the OVX+E2 as compared with the OVX+Pla group. NG‐nitro‐L‐arginine methyl ester, administered via drinking water, reduced the difference in these responses. Furthermore, this stress increased plasma nitrotyrosine and decreased plasma nitric oxide (NO) metabolites only in the OVX+Pla group. We demonstrated that estrogen replacement suppresses cardiovascular responses to psychological stress, at least in part by improving NO bioavailability in ovariectomized rats.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1410.045