Epidermal growth factor receptor (EGFR), proliferating cell nuclear antigen (PCNA) and Ki-67 antigen in laryngeal epithelial lesions

The epidermal growth factor receptor (EGFR), proliferating cell nuclear antigen (PCNA) and Ki-67 immunostaining in paraffin sections from 154 cases of laryngeal squamous cell carcinoma, 25 specimens of normal and hyperplastic laryngeal epithelium, and 21 preneoplastic lesions was examined. The diffe...

Full description

Saved in:
Bibliographic Details
Published in:Oral oncology 1999-03, Vol.35 (2), p.180-186
Main Authors: Kręcicki, Tomasz, Jeleń, Michał, Zalesska-Kręcicka, Maria, Rak, Jerzy, Szkudlarek, Teresa, Jeleń-Krzeszewska, Joanna
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
EGFR
Ent. Stomatology
Female
Humans
Hyperplasia - metabolism
Hyperplasia - pathology
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Ki-67
Ki-67 Antigen - metabolism
Laryngeal lesions
Laryngeal Neoplasms - metabolism
Laryngeal Neoplasms - pathology
Male
Medical sciences
Middle Aged
Neoplasm Staging
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
PCNA
Proliferating Cell Nuclear Antigen - metabolism
Receptor, Epidermal Growth Factor - metabolism
Staining and Labeling
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The epidermal growth factor receptor (EGFR), proliferating cell nuclear antigen (PCNA) and Ki-67 immunostaining in paraffin sections from 154 cases of laryngeal squamous cell carcinoma, 25 specimens of normal and hyperplastic laryngeal epithelium, and 21 preneoplastic lesions was examined. The difference of EGFR expression and PCNA score between laryngeal cancer and dysplastic lesions vs normal and hyperplastic epithelium was significant. There was significant difference in Ki-67 score between malignant vs premalignant lesions and normal and hyperplastic epithelium. There was significant correlation between PCNA score and histopathological grading of the tumour. The highest PCNA expression was detected in stage G3. Our findings have shown that PCNA and Ki-67 staining can be used as a marker of cell proliferative activity in laryngeal epithelial lesions. EGFR, PCNA and Ki-67 expression correlate with severity of laryngeal lesions. PCNA immunostaining can aid in estimating the histological grade of malignant lesions.
ISSN:1368-8375
1879-0593
DOI:10.1016/S1368-8375(98)00100-6