p53 overexpression in oral mucosa in relation to smoking

The tumour‐suppressor protein p53 is mutated in many head and neck squamous cell carcinomas (HNSCCs). In this immunohistochemical study, similar numbers of p53‐overexpressing cells were uniformly distributed throughout normal oral epithelium, irrespective of different smoking habits or the presence...

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Bibliographic Details
Published in:The Journal of pathology 1999-03, Vol.187 (4), p.469-474
Main Authors: van Oijen, Monique G. C. T., van de Craats, Johanna G., Slootweg, Pieter J.
Format: Article
Language:English
Subjects:
Adult
Aged
alcohol
Biological and medical sciences
Carcinoma, Squamous Cell - metabolism
Female
field cancerization
head and neck cancer
Head and Neck Neoplasms - metabolism
Humans
Immunoenzyme Techniques
immunohistochemistry
Male
Medical sciences
Middle Aged
Mouth Mucosa - metabolism
Neoplasm Proteins - metabolism
Otorhinolaryngology. Stomatology
p53
Smoking - metabolism
tobacco
Tumor Suppressor Protein p53 - metabolism
Tumors
tumourigenesis
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:The tumour‐suppressor protein p53 is mutated in many head and neck squamous cell carcinomas (HNSCCs). In this immunohistochemical study, similar numbers of p53‐overexpressing cells were uniformly distributed throughout normal oral epithelium, irrespective of different smoking habits or the presence of an adjacent HNSCC. In a previous study, an increased number of proliferating cells were observed in normal oral mucosa from (ex)‐smoking individuals and the present observations indicate that overexpression of p53 does not play a role in this increase. In contrast, focally overexpressed p53 occurred more frequently (p 
ISSN:0022-3417
1096-9896
DOI:10.1002/(SICI)1096-9896(199903)187:4<469::AID-PATH262>3.0.CO;2-3