The significance of autoantibodies against oxidatively modified low-density lipoprotein (LDL) in patients with psoriasis

Psoriasis is associated with changes in plasma lipid and lipoproteins, which may play a role in the development of occlusive vascular disease. The oxidation of low-density lipoprotein (LDL) is considered a key event in the development and progression of atherosclerosis. Autoantibodies against oxidiz...

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Bibliographic Details
Published in:Clinica chimica acta 1999-06, Vol.284 (1), p.81-88
Main Authors: Örem, Asim, Çimşit, Gülseren, Değer, Orhan, Örem, Cihan, Vanizor, Birgül
Format: Article
Language:English
Subjects:
Acute-Phase Proteins - metabolism
Adolescent
Adult
Autoantibodies - blood
Biological and medical sciences
Dermatology
Female
Humans
Lipids - blood
Lipoproteins - blood
Lipoproteins, LDL - immunology
Male
Medical sciences
Middle Aged
Oxidation-Reduction
Psoriasis - immunology
Psoriasis. Parapsoriasis. Lichen
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Summary:Psoriasis is associated with changes in plasma lipid and lipoproteins, which may play a role in the development of occlusive vascular disease. The oxidation of low-density lipoprotein (LDL) is considered a key event in the development and progression of atherosclerosis. Autoantibodies against oxidized LDL (auAb-oxLDL) may contribute to understanding the relationship between oxidative processes and development of atherosclerosis. Thirty-three patients with psoriasis and 30 matched control subjects were investigated. LDL oxidation was evaluated as the presence of autoantibodies against LDL oxidatively modified with Cu ++, by an ELISA system in the patients and control sera. AuAb-ox LDL levels of the patients were found to be significantly increased compared with a control group. 42% of the patients and 3.3% of the control subjects had higher auAb-ox LDL levels than the cut-off point (352 mU/ml). The levels of auAb-ox LDL were found to be correlated with PASI score ( r=0.67, p
ISSN:0009-8981
1873-3492
DOI:10.1016/S0009-8981(99)00062-5