L-Purine Nucleosides as Selective Antimalarials

L-nucleosides selectively enter malaria infected erythrocytes and have the unique ability to be metabolised by the malarial adenosine deaminase. This has allowed us to design novel L-nucleosides as potential anti-malarials.

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Bibliographic Details
Published in:Nucleosides & nucleotides 1999-04, Vol.18 (4-5), p.885-889
Main Authors: Gero, Annette M., Perrone, Gabriel, Brown, David M., Hall, Simone T., Chu, Chung K.
Format: Article
Language:English
Subjects:
Adenosine Deaminase - metabolism
Animals
Antimalarials - pharmacokinetics
Antimalarials - pharmacology
Chromatography, High Pressure Liquid
Erythrocytes - parasitology
Plasmodium falciparum - enzymology
Purine Nucleosides - pharmacokinetics
Purine Nucleosides - pharmacology
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Description
Summary:L-nucleosides selectively enter malaria infected erythrocytes and have the unique ability to be metabolised by the malarial adenosine deaminase. This has allowed us to design novel L-nucleosides as potential anti-malarials.
ISSN:0732-8311
DOI:10.1080/15257779908041593