New Series of Mixed Pronucleotides. Synthesis and Anti-HIV Activities of Mononucleoside Phenyl SATE Phosphotriesters

The synthesis and anti-HIV activities of phenyl S-pivaloyl-2-thioethyl (tBuSATE) phosphotriesters of AZT and d4T are reported. These compounds show similar activity compared to bis(tBuSATE) phosphotriesters and appear to be able to deliver the corresponding 5′-mononucleotides inside the cells.

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Bibliographic Details
Published in:Nucleosides & nucleotides 1999-04, Vol.18 (4-5), p.1025-1026
Main Authors: Schlienger, N., Peyrottes, S., Aubertin, A-M., Gosselin, G., Imbach, J-L., Périgaud, C.
Format: Article
Language:English
Subjects:
AIDS/HIV
Anti-HIV Agents - chemical synthesis
Anti-HIV Agents - pharmacology
Cell Line
HIV-1 - drug effects
HIV-1 - physiology
Humans
Stavudine - analogs & derivatives
Stavudine - chemical synthesis
Stavudine - pharmacology
Virus Replication - drug effects
Zidovudine - analogs & derivatives
Zidovudine - chemical synthesis
Zidovudine - pharmacology
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Summary:The synthesis and anti-HIV activities of phenyl S-pivaloyl-2-thioethyl (tBuSATE) phosphotriesters of AZT and d4T are reported. These compounds show similar activity compared to bis(tBuSATE) phosphotriesters and appear to be able to deliver the corresponding 5′-mononucleotides inside the cells.
ISSN:0732-8311
DOI:10.1080/15257779908041638