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Cerebellar GABA A receptors and anxiolytic action of diazepam
Alcohol-sensitive ANT rats have a point mutation in the cerebellum-enriched GABA A receptor α6 subunit, which makes this subunit and the ANT rats in vivo highly sensitive to benzodiazepine agonists. In the elevated plus maze test of anxiety, diazepam produced a greater anxiolytic response in the ANT...
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| Published in: | Brain research 1999-08, Vol.837 (1), p.184-187 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 187 |
| container_issue | 1 |
| container_start_page | 184 |
| container_title | Brain research |
| container_volume | 837 |
| creator | Vekovischeva, Olga Y. Haapalinna, Antti Sarviharju, Maija Honkanen, Aapo Korpi, Esa R. |
| description | Alcohol-sensitive ANT rats have a point mutation in the cerebellum-enriched GABA
A receptor α6 subunit, which makes this subunit and the ANT rats in vivo highly sensitive to benzodiazepine agonists. In the elevated plus maze test of anxiety, diazepam produced a greater anxiolytic response in the ANT rats than in the control, alcohol-insensitive AT rats. The ANT rats were less sensitive to the sedative effect of diazepam in the staircase test of exploration. The results thus suggest that the mutant cerebellar granule cell layer receptors can participate in GABA
A receptor-activation-induced anxiolysis. |
| doi_str_mv | 10.1016/S0006-8993(99)01691-1 |
| format | article |
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| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 1999-08, Vol.837 (1), p.184-187 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Analysis of Variance Animals Anxiety Anxiety - physiopathology Benzodiazepine Cerebellum Cerebellum - physiology Diazepam - pharmacology Elevated plus maze Ethanol GABA A receptor subtype Male Maze Learning - drug effects Maze Learning - physiology Point Mutation Rats Rats, Mutant Strains Reaction Time Receptors, GABA-A - genetics Receptors, GABA-A - physiology |
| title | Cerebellar GABA A receptors and anxiolytic action of diazepam |
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