Chemical and Enzymatic Synthesis and Antiviral Properties of 2′-Deoxy-2′-fluoroguanosine

Chemical and enzymatic methods were employed for the synthesis of the title compound, 2′F-Guo 7. High antiviral activity of 2′F-Guo was established in chick embryo cells infected with influenza virus FPV/Rostock/34 (H7N1) and herpes simplex virus (HSV) type I (1C strain).

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Bibliographic Details
Published in:Nucleosides & nucleotides 1999-04, Vol.18 (4-5), p.687-688
Main Authors: Zaitseva, Galina V., Zinchenko, Anatoli I., Barai, Vladimir N., Pavlova, N. I., Boreko, Evgeny I., Mikhailopulo, Igor A.
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - chemical synthesis
Antiviral Agents - pharmacology
Chick Embryo
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - chemical synthesis
Deoxyguanosine - pharmacology
Herpesvirus 1, Human - drug effects
Orthomyxoviridae - drug effects
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Description
Summary:Chemical and enzymatic methods were employed for the synthesis of the title compound, 2′F-Guo 7. High antiviral activity of 2′F-Guo was established in chick embryo cells infected with influenza virus FPV/Rostock/34 (H7N1) and herpes simplex virus (HSV) type I (1C strain).
ISSN:0732-8311
2332-3892
DOI:10.1080/15257779908041541