Anonymous Unlinked Testing as a Sentinel Approach: Experience in Germany

Study objective-To establish a laboratory sentinel as a supplementary instrument for monitoring the seroprevalence of HIV among childbearing women as a proxy to the heterosexually active population. Design/Setting-Anonymous unlinked testing of neonatal dried blood spots has been performed in central...

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Bibliographic Details
Published in:Journal of epidemiology and community health (1979) 1998-04, Vol.52, p.25S-27S
Main Authors: Siedler, A., Hamouda, O., Schwartländer, B.
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS
AIDS/HIV
Biological and medical sciences
Blood
Epidemiology
Ethics, Medical
Female
General aspects
Germany - epidemiology
HIV
HIV infections
HIV Infections - blood
HIV Seroprevalence
Human viral diseases
Humans
Infant, Newborn
Infections
Infectious diseases
Longitudinal Studies
Male
Medical sciences
Metabolism, Inborn Errors - diagnosis
Newborns
Planification. Prevention (methods). Intervention. Evaluation
Pregnancy
Public health
Public health. Hygiene
Public health. Hygiene-occupational medicine
Sentinel Surveillance
Specimens
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Study objective-To establish a laboratory sentinel as a supplementary instrument for monitoring the seroprevalence of HIV among childbearing women as a proxy to the heterosexually active population. Design/Setting-Anonymous unlinked testing of neonatal dried blood spots has been performed in central laboratories of three federal states since 1993. The survey uses residual dried blood spots collected on Guthrie cards for screening of infants for metabolic disorders. These are eluted and tested for HIV antibodies. Data retained with the specimen are only district of residence along with year and month of birth. Participants-Because maternal IgG crosses the placenta before birth, the presence of antibodies in newborns reflects the infection status of the mother. Childbearing women are fairly representative for the heterosexually active general population. Main results-The observed HIV prevalence in childbearing women of less than 1 per thousand confirms the assumption of a low rate of HIV infection in the general population. Significant time trends could not be detected, but HIV prevalence was higher in metropolitan compared with rural areas. Conclusions-Laboratory sentinels in general and the anonymous unlinked testing of neonatal dried blood spots in particular can supply additional information on HIV seroprevalence. This surveillance system could be expanded to utilise residual samples of other sources as well as to monitor the immunity against specific vaccine preventable diseases and other infectious diseases of public health relevance.
ISSN:0143-005X
1470-2738