Deoxyribonuclease activity in biological fluids of healthy donors and cancer patients

Integral activity of neutral deoxyribonucleases in the plasma and urine or donors, patients with benign prostatic hyperplasia, and patients with stomach and prostatic cancer was studied by IFA based on hydrolysis of DNA fragment modified with haptene molecules. In donors plasma deoxyribonuclease act...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-07, Vol.146 (1), p.89-91
Main Authors: Tamkovich, S. N, Cherepanova, A. V, Bryzgunova, O. E, Kolesnikova, E. V, Permyakova, V. I, Vlassov, V. V, Laktionov, P. P
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
blood plasma
Body Fluids - enzymology
Cell Biology
deoxyribonuclease activity
Deoxyribonucleases - blood
Deoxyribonucleases - urine
Female
Humans
Internal Medicine
Laboratory Medicine
Male
Neoplasms - blood
Neoplasms - enzymology
Neoplasms - urine
Oncology
Pathology
Prostatic Hyperplasia - blood
Prostatic Hyperplasia - enzymology
Prostatic Hyperplasia - urine
prostatic neoplasms
stomach neoplasms
urine
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Summary:Integral activity of neutral deoxyribonucleases in the plasma and urine or donors, patients with benign prostatic hyperplasia, and patients with stomach and prostatic cancer was studied by IFA based on hydrolysis of DNA fragment modified with haptene molecules. In donors plasma deoxyribonuclease activity was 0.16±0.04, urinary activity 1.49±1.41 act. U/ml. In patients with benign prostatic hyperplasia and malignant tumors the integral activity of blood deoxyribonucleases was significantly below the normal, and in tumors it did not correlate with tumor size and disease stage. A significant correlation between blood and urinary deoxyribonuclease activities was detected.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-008-0213-4