Effects of GSM-Modulated Radiofrequency Electromagnetic Fields on Mouse Bone Marrow Cells

• Published in: Radiation research 2008-12, Vol.170 (6), p.803-810
• Main Authors: Prisco, Maria Grazia, Nasta, Francesca, Rosado, Maria Manuela, Lovisolo, Giorgio Alfonso, Marino, Carmela, Pioli, Claudio
• Format: Article
• Language: English
• Subjects: Animals; B lymphocytes; B-Lymphocytes - cytology; B-Lymphocytes - radiation effects; Bone marrow; Bone marrow cells; Bone Marrow Cells - metabolism; Bone Marrow Cells - radiation effects; Bone Marrow Transplantation; Cell Count; Cell Differentiation - radiation effects; Cell growth; Cell phones; Cell Proliferation - radiation effects; Electromagnetic Fields; Female; Lymphocytes; Mice; Radio Waves; REGULAR ARTICLES; Space life sciences; Spleen; Spleen - cytology; Spleen - radiation effects; Spleen cells; Survival Rate; T-Lymphocytes - cytology; T-Lymphocytes - radiation effects; Thymus Gland - cytology; Thymus Gland - radiation effects
• ISSN: 0033-7587; 1938-5404
• DOI: 10.1667/RR1213.1

Prisco, M. G., Nasta, F., Rosado, M. M., Lovisolo, G. A., Marino, C. and Pioli, C. Effects of GSM-Modulated Radiofrequency Electromagnetic Fields on Mouse Bone Marrow Cells. Radiat. Res. 170, 803–810 (2008). We examined the effects of in vivo exposure to a GSM-modulated 900 MHz RF field on the ability of bone marrow cells to differentiate, colonize lymphatic organs, and rescue lethally X-irradiated mice from death. X-irradiated mice were injected with medium alone or containing bone marrow cells from either RF-field-exposed (SAR 2 W/kg, 2 h/day, 5 days/ week, 4 weeks) or sham-exposed or cage control donor mice. Whereas all mice injected with medium alone died, mice that received bone marrow cells survived. Three and 6 weeks after bone marrow cell transplantation, no differences in thymus cellularity and in the frequencies of differentiating cell subpopulations (identified by CD4/CD8 expression) were observed among the three transplanted groups. Mitogen-induced thymocyte proliferation yielded comparable levels in all transplanted groups. As to the spleen, no effects of the RF-field exposure on cell number, percentages of B and T (CD4 and CD8) cells, B- and T-cell proliferation, and IFN-γ production were found in transplanted mice. In conclusion, our results show no effect of in vivo exposure to GSM-modulated RF fields on the ability of bone marrow precursor cells to home and colonize lymphoid organs and differentiate in phenotypically and functionally mature T and B lymphocytes.