Effects of fenamate on inhibitory postsynaptic currents in Purkinje’s cells

The effects of nonsteroid antiinflammatory drugs of the fenamate group (mefenamic and tolfenamic acids) on spontaneous miniature inhibitory postsynaptic currents in Purkinje’s cells were studied in mouse cerebellar slices by the whole cell patch-clamp method. Both drugs in concentrations of 3–30 µM...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-05, Vol.145 (5), p.564-568
Main Author: Dvorzhak, A. Yu
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory agents
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cerebellum
gamma-Aminobutyric Acid - metabolism
gamma-Aminobutyric Acid - pharmacology
In Vitro Techniques
Inhibitory postsynaptic potentials
Inhibitory Postsynaptic Potentials - drug effects
Internal Medicine
Laboratory Medicine
Mefenamic Acid - pharmacology
Mice
Mice, Inbred C57BL
Miniature Postsynaptic Potentials - drug effects
ortho-Aminobenzoates - pharmacology
Patch-Clamp Techniques
Pathology
Purkinje Cells - drug effects
Purkinje Cells - metabolism
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Summary:The effects of nonsteroid antiinflammatory drugs of the fenamate group (mefenamic and tolfenamic acids) on spontaneous miniature inhibitory postsynaptic currents in Purkinje’s cells were studied in mouse cerebellar slices by the whole cell patch-clamp method. Both drugs in concentrations of 3–30 µM significantly prolonged miniature inhibitory postsynaptic currents and reduced their amplitude.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-008-0144-0