Intensity of Infection in AIDS-Related Intestinal Microsporidiosis

To quantify intensity of infection in AIDS-related microsporidiosis, 20 patients with known microsporidiosis submitted stools for quantitative spore counts after staining with a calcofluor white stain. Nine patients collected stools for 24 h, for assessment of daily spore excretion, stool-to-stool v...

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Bibliographic Details
Published in:The Journal of infectious diseases 1999-09, Vol.180 (3), p.929-932
Main Authors: Goodgame, Richard, Stager, Charles, Marcantel, Brian, Alcocer, Eduardo, Segura, Ana Marie
Format: Article
Language:English
Subjects:
AIDS-Related Opportunistic Infections - parasitology
AIDS-Related Opportunistic Infections - physiopathology
AIDS/HIV
Animals
Atrophy
Biological and medical sciences
Biopsies
Biopsy
Concise Communications
Cryptosporidiosis
Excretion
Feces - parasitology
Fungal spores
Human protozoal diseases
Humans
Infections
Infectious diseases
Inflammation
Intestine, Small - parasitology
Intestine, Small - pathology
Medical sciences
Microbial colony count
Microsporida
Microsporidiosis
Parasitic diseases
Protozoal diseases
Protozoan Infections - physiopathology
Reproducibility of Results
Small intestine
Spores
Unclassified Microsporidia
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Summary:To quantify intensity of infection in AIDS-related microsporidiosis, 20 patients with known microsporidiosis submitted stools for quantitative spore counts after staining with a calcofluor white stain. Nine patients collected stools for 24 h, for assessment of daily spore excretion, stool-to-stool variation in spore excretion, and patient-to-patient variation in intensity of infection. The number of organisms seen in small bowel biopsy specimens from 7 patients was compared with quantitative fecal spore excretion. Fecal spore concentration in 20 patients ranged from 4.5 × 105 to 4.4 × 108 spores/mL of stool. There was a strong correlation between fecal spore excretion and duodenal biopsy spore counts (r = .82; P < .024). Microsporidium infections in AIDS patients can be quantified by counting spores in stool and by small bowel biopsy. Variations in intensity of infection from patient to patient are great and are similar to those in AIDS-related Cryptosporidium infection.
ISSN:0022-1899
1537-6613
DOI:10.1086/314914