Increased Urine Interleukin-6 Concentrations Correlate with Pyelonephritic Changes on 99mTc-Dimercaptosuccinic Acid Scans in Neonates with Urinary Tract Infections

Interleukin (IL)—6 and —8 are important inflammatory cytokines in bacterial infections. Their serum and urine concentrations were measured in 27 neonates with urinary tract infection (UTI) at onset and the second week of therapy, as well as in 23 control neonates. Escherichia coli was isolated in 89...

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Bibliographic Details
Published in:The Journal of infectious diseases 1999-09, Vol.180 (3), p.904-907
Main Authors: Roilides, Emmanuel, Papachristou, Fotis, Gioulekas, Elias, Tsaparidou, Sevasti, Karatzas, Nicolas, Sotiriou, John, Tsiouris, John
Format: Article
Language:English
Subjects:
Bacterial diseases
Bacterial diseases of the urinary system
Biological and medical sciences
Female
Follow-Up Studies
Human bacterial diseases
Humans
Infant, Newborn
Infectious diseases
Interleukin-6 - urine
Interleukin-8 - urine
Kidney - diagnostic imaging
Male
Medical sciences
Pyelonephritis - complications
Pyelonephritis - diagnostic imaging
Pyelonephritis - urine
Radionuclide Imaging
Radiopharmaceuticals
Technetium Tc 99m Dimercaptosuccinic Acid
Urinary Tract Infections - complications
Urinary Tract Infections - diagnostic imaging
Urinary Tract Infections - urine
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Summary:Interleukin (IL)—6 and —8 are important inflammatory cytokines in bacterial infections. Their serum and urine concentrations were measured in 27 neonates with urinary tract infection (UTI) at onset and the second week of therapy, as well as in 23 control neonates. Escherichia coli was isolated in 89% of cases. 99mTc-dimercaptosuccinic acid (99mTc-DMSA) scans were performed between the 10th and 90th days after UTI and showed pyelonephritic changes in 15 neonates (56%). Increased IL-6 and IL-8 concentrations were found in urine but not in serum within the first 24 h after presumptive diagnosis of UTI (P = .036 and .010, respectively), suggesting that the neonatal urinary tract can respond to uropathogens by producing inflammatory cytokines. Urine concentrations of IL-6 correlated with findings of renal changes in 99mTc-DMSA scans (P = .012) and thus may serve as a marker of renal parenchymal outcome. All neonates exhibited undetectable urine cytokine levels during the second week of therapy.
ISSN:0022-1899
1537-6613
DOI:10.1086/314960