Use of primary human fetal chondroblast culture for xenotransplantation into rat articular cartilage defect

The possibility of xenotransplantation of human fetal chondroblasts was studied. Filling of the rat articular cartilage defect with a tissue-engineering construction based on primary culture of human fetal chondroblasts and chitosan gel caused no immune rejection over 60 days and provided the format...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-07, Vol.146 (1), p.124-128
Main Authors: Sakharov, A. V, Makeyev, A. A, Efremov, A. V, Valeyeva, V. A, Burova, L. G, Kolokoltseva, T. D, Lukanina, S. N, Pykhtina, M. B, Ryabchikova, E. I
Format: Article
Language:English
Subjects:
Animals
articular cartilage
Biomedical and Life Sciences
Biomedicine
Cartilage, Articular - pathology
Cartilage, Articular - transplantation
Cell Biology
Cells, Cultured
chondroblasts
Chondrocytes - cytology
Chondrocytes - transplantation
Fetus - cytology
Humans
Internal Medicine
Laboratory Medicine
Pathology
Rats
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
Transplantation, Heterologous - methods
xenotransplantation
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Summary:The possibility of xenotransplantation of human fetal chondroblasts was studied. Filling of the rat articular cartilage defect with a tissue-engineering construction based on primary culture of human fetal chondroblasts and chitosan gel caused no immune rejection over 60 days and provided the formation of organotypical regenerate due to proliferation and differentiation of donor fetal chondroblasts and their integration in the recipient cartilage tissue.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-008-0220-5