X-ray scatter signatures for normal and neoplastic breast tissues

Measurements of breast tissue scattering properties have been made in an energy dispersive x-ray diffraction system over the momentum transfer range of 0.70 to 3.50 nm(-1). One hundred samples of excised tissue have been used. Results from the diffraction system have been compared with the histologi...

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Bibliographic Details
Published in:Physics in medicine & biology 1999-07, Vol.44 (7), p.1791-1802
Main Authors: Kidane, G, Speller, R D, Royle, G J, Hanby, A M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Breast
Breast Diseases - diagnostic imaging
Breast Neoplasms - diagnostic imaging
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Mammography
Medical sciences
Middle Aged
Reference Values
Scattering, Radiation
Tumors
X-Ray Diffraction
X-Rays
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Summary:Measurements of breast tissue scattering properties have been made in an energy dispersive x-ray diffraction system over the momentum transfer range of 0.70 to 3.50 nm(-1). One hundred samples of excised tissue have been used. Results from the diffraction system have been compared with the histological analysis for each individual sample. It has been found that tissue types can be characterized on the basis of the shape of the scatter spectrum and on its relative intensity. The shapes are significantly different between tissue types in the range 1.0 to 1.8 nm(-1) and suggest that if particular values of momentum transfer are monitored, a discriminating signal could be obtained. Analysis of the maximum intensity in the signature also reveals a change of up to a factor of 2 between adipose and fat-free tissues.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/44/7/316