Thin Glomerular Basement Membranes in Patients with Hematuria and Minimal Change Disease

A detailed morphometric analysis of glomerular basement membrane (GBM) thickness was carried out on biopsies from 16 patients exhibiting normal histology and unremarkable immunofluorescence. Eleven of these patients presented with proteinuria, 8 in the nephrotic syndrome range, while 5 had hematuria...

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Bibliographic Details
Published in:Ultrastructural pathology 1999, Vol.23 (3), p.149-156
Main Authors: Marquez, B, Stavrou, F, Zouvani, I, Anastasiades, E, Patsias, C, Pierides, A, Kyriacou, K
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Basement Membrane - pathology
Biopsy
Child
Child, Preschool
Female
Fluorescent Antibody Technique
Glomerular Mesangium - pathology
Hematuria - pathology
Humans
Male
Microscopy, Electron
Middle Aged
Minimal Change Disease
Morphometry
Thin Glomerular
Basement Membrane
Nephrosis, Lipoid - pathology
Reference Values
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Summary:A detailed morphometric analysis of glomerular basement membrane (GBM) thickness was carried out on biopsies from 16 patients exhibiting normal histology and unremarkable immunofluorescence. Eleven of these patients presented with proteinuria, 8 in the nephrotic syndrome range, while 5 had hematuria as well. The remaining 5 patients presented with hematuria only. Eight patients had an initial diagnosis of minimal change disease, 4 were diagnosed as thin-membrane nephropathy, 2 had Alport syndrome, and the remaining 2 had hypertensive nephropathy. Quantitative morphometric analysis of GBM identified 3 subsets of patients. The first subset consisted of 6 patients: 5 adults, with an average GBM width of 361+/- 34 nm, and 1 child. The second subset included 8 patients with thin GBMs and a mean thickness of 253+/- 15 nm. The last subset comprised 2 patients with Alport syndrome showing marked variability in GBM thickness. This study has confirmed the presence of thin GBMs in hematurics, but has also revealed GBM thinning in 50% of patients with a diagnosis of minimal change disease.
ISSN:0191-3123
1521-0758
DOI:10.1080/019131299281644