Use of propranolol and potassium iodate in the presurgical management of hyperthyroid cats

A prospective study was carried out using a combination of propranolol and potassium iodate to assess whether there were beneficial effects in preparing hyperthyroid cats for surgk thyroidectomy. Group A (n = 11) received propranolol from days 1 to 10, followed by propranolol and potassium iodate fr...

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Bibliographic Details
Published in:Journal of small animal practice 1999-07, Vol.40 (7), p.307-315
Main Authors: Foster, D.J, Thoday, K.L
Format: Article
Language:English
Subjects:
Animals
Cat Diseases - drug therapy
Cat Diseases - surgery
Cats
Drug Administration Schedule
drugs
Female
hyperthyroidism
Hyperthyroidism - drug therapy
Hyperthyroidism - surgery
Hyperthyroidism - veterinary
Liver - drug effects
Liver - pathology
Male
medical treatment
Potassium Iodide - therapeutic use
Preoperative Care - veterinary
Propranolol - therapeutic use
Prospective Studies
Reference Values
surgery
Sympatholytics - therapeutic use
Thyroid Gland - drug effects
thyroid hormones
Thyroidectomy - veterinary
Thyroxine - blood
Triiodothyronine - blood
Triiodothyronine, Reverse - blood
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Summary:A prospective study was carried out using a combination of propranolol and potassium iodate to assess whether there were beneficial effects in preparing hyperthyroid cats for surgk thyroidectomy. Group A (n = 11) received propranolol from days 1 to 10, followed by propranolol and potassium iodate from days 11 to 20; group B (n = 10) received the reverse regimen. Blood samples were taken daily for subsequent determination of serum total L‐thyroxine (TT4), L‐triiodothyronine (TT3) and reverse T3 (rT3) concentrations. The signs of hyperthyroidism improved in all Cats over the treatment period. At surgery, 36 per cent of the cats in group A had reference range serum TT4 concentrations, while 89 per cent with initially elevated TT3 concentrations had reference range concentrations. In group B., 10 per cent of the cats had reference range TT4 concentrations, while 75 per cent with initially elevated TT3 concentrations had reference range concentrations. The drug regimen used in group A was better tolerated and more effective and offers an alternative before thyroidectomy in cats that cannot tolerate carbimazole.
ISSN:0022-4510
1748-5827
DOI:10.1111/j.1748-5827.1999.tb03087.x