Prognostic significance of standardized AgNOR analysis in early and advanced gastric carcinomas

To assess the prognostic significance of silver-stained nucleolar organizer region (AgNOR) proteins, a standardized AgNOR analysis was performed on 78 patients affected by early (EGC, n=24) or advanced (AGC, n=54) gastric carcinomas. The histopathological diagnosis, grading and staging were done acc...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 1998-09, Vol.433 (3), p.261-266
Main Authors: GIUFFRE, G, CARUSO, R. A, BARRESI, G, TUCCARI, G
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemistry
Adenocarcinoma - diagnosis
Adenocarcinoma - mortality
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Female
Follow-Up Studies
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Middle Aged
Nucleolus Organizer Region - chemistry
Prognosis
Silver Staining
Stomach Neoplasms - chemistry
Stomach Neoplasms - diagnosis
Stomach Neoplasms - mortality
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Survival Rate
Tumors
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Summary:To assess the prognostic significance of silver-stained nucleolar organizer region (AgNOR) proteins, a standardized AgNOR analysis was performed on 78 patients affected by early (EGC, n=24) or advanced (AGC, n=54) gastric carcinomas. The histopathological diagnosis, grading and staging were done according to WHO and UICC recommendations; the mean follow-up time was 56.9 months. Visualization and quantification of AgNORs were made in formalin-fixed, paraffin-embedded sections as specified in the guidelines of the Committee on AgNOR Quantification (1995). Statistical analysis was performed on the mean AgNOR area values (NORA). Highly significant differences (P5.213 microm2) had a worse prognosis. Finally, using Cox multiple regression analysis, the AgNOR quantity emerged as a useful independent prognostic variable to predict the final outcome of patients affected by EGC or AGC.
ISSN:0945-6317
1432-2307
DOI:10.1007/s004280050245