Fungal intracranial aneurysm in a child with familial chronic mucocutaneous candidiasis

We report on a patient who presented at 5 years of age with a hemiparesis due to a middle cerebral artery infarction. An embolism had originated from a mycotic aneurysm located in the internal carotid artery. For several months prior to admission he had been suffering from therapeutically resistant...

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Bibliographic Details
Published in:European journal of pediatrics 1999-08, Vol.158 (8), p.650-652
Main Authors: LOEYS, B. L, VAN COSTER, R. N, DEFREYNE, L. R, LEROY, J. G
Format: Article
Language:English
Subjects:
Aneurysm, Infected - etiology
Biological and medical sciences
Candidiasis, Chronic Mucocutaneous - complications
Candidiasis, Chronic Mucocutaneous - genetics
Child, Preschool
Female
Human mycoses
Humans
Infectious diseases
Intracranial Aneurysm - etiology
Intracranial Aneurysm - microbiology
Medical sciences
Mycoses
Mycotic sepsis
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Summary:We report on a patient who presented at 5 years of age with a hemiparesis due to a middle cerebral artery infarction. An embolism had originated from a mycotic aneurysm located in the internal carotid artery. For several months prior to admission he had been suffering from therapeutically resistant candidiasis of the mouth and nails. Family history revealed chronic mycotic infections of the skin, hair, nails and mouth in the father and paternal grandmother suggestive of chronic mucocutaneous candidiasis with autosomal dominant mode of inheritance. Clipping of the aneurysm, after 3 months of anti-mycotic treatment, followed by sustained treatment with itraconazole and fluconazole, led to a favourable outcome. Chronic mucocutaneous candidiasis can be associated with an intracranial aneurysm and complicated by cerebral infarction.
ISSN:0340-6199
1432-1076
DOI:10.1007/s004310051169