Osteocalcin-immunoreactive primary sensory neurons in the rat spinal and trigeminal nervous systems

• Published in: Brain research 1999-08, Vol.838 (1), p.205-209
• Main Authors: Ichikawa, Hiroyuki, Itota, Toshiyuki, Torii, Yasuhiro, Inoue, Kiyoshi, Sugimoto, Tomosada
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Calcitonin gene-related peptide; Dorsal root ganglion; Fundamental and applied biological sciences. Psychology; Ganglia, Spinal - chemistry; Ganglia, Spinal - cytology; Immunohistochemistry; Male; Mesencephalic trigeminal tract nucleus; Mesencephalon - chemistry; Mesencephalon - cytology; Neurons, Afferent - chemistry; Osteocalcin; Osteocalcin - analysis; Parvalbumin; Rats; Rats, Sprague-Dawley; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Spinal Cord - chemistry; Spinal Cord - cytology; Trigeminal ganglion; Trigeminal Nuclei - chemistry; Trigeminal Nuclei - cytology; Vertebrates: nervous system and sense organs
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/S0006-8993(99)01710-2

Osteocalcin-immunoreactivity (OC-ir) was examined in spinal and trigeminal primary sensory neurons of the adult rat. Sixteen percent of dorsal root ganglion (DRG) neurons were immunoreactive (ir) for this protein. These neurons were mostly large and measured 594–4583 μm 2 (mean±S.D.=2243±748 μm 2). Thirty-four percent of DRG neurons >1200 μm 2 and 4% of those in the range 600–1200 μm 2 showed the ir. Virtually all DRG neurons 800 μm 2 and 6% of those