Capillary zone electrophoresis determination of galanthamine in biological fluids and pharmaceutical preparatives: Experimental design and artificial neural network optimization

Galanthamine is a third‐generation cholinesterase inhibitor used against Alzheimer's disease. New analytical methods for the determination of galanthamine in pharmaceutical preparatives and biological fluids, such as urine and serum, were developed. An experimental design and artificial neural...

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Bibliographic Details
Published in:Electrophoresis 1999-07, Vol.20 (10), p.1993-1997
Main Authors: Pokorná, Lenka, Revilla, Alma, Havel, Josef, Patočka, Jiří
Format: Article
Language:English
Subjects:
Alzheimer Disease - drug therapy
Artificial neural networks
Body Fluids - chemistry
Cholinesterase Inhibitors - analysis
Drug monitoring
Electrophoresis, Capillary - methods
Factorial design
Galantamine - analysis
Galantamine - blood
Galantamine - urine
Galanthamine
Humans
Hydrogen-Ion Concentration
Neural Networks (Computer)
Pharmaceutical Preparations - chemistry
Regression Analysis
Reproducibility of Results
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Summary:Galanthamine is a third‐generation cholinesterase inhibitor used against Alzheimer's disease. New analytical methods for the determination of galanthamine in pharmaceutical preparatives and biological fluids, such as urine and serum, were developed. An experimental design and artificial neural network approach were used for method optimization. Thirty‐five ppb of galanthamine were determined in serum samples (with addition of 10 mM magnesium chloride and using solid‐phase preconcentration).
ISSN:0173-0835
1522-2683
DOI:10.1002/(SICI)1522-2683(19990701)20:10<1993::AID-ELPS1993>3.0.CO;2-5