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Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance
Objective. To assess the effects of lifestyle intervention on cardiovascular risk factors in general and especially on fibrinolysis. Design. Randomized clinical study. Subjects. A total of 186 subjects with impaired glucose tolerance and obesity. Interventions. The intervention programme included a...
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| Published in: | Journal of internal medicine 1999-07, Vol.246 (1), p.105-112 |
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| container_title | Journal of internal medicine |
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| creator | Lindahl, B. Nilsson, T. K. Jansson, J.‐H. Asplund, K. Hallmans, G. |
| description | Objective. To assess the effects of lifestyle intervention on cardiovascular risk factors in general and especially on fibrinolysis.
Design. Randomized clinical study.
Subjects. A total of 186 subjects with impaired glucose tolerance and obesity.
Interventions. The intervention programme included a low‐fat, high‐fibre diet and regular physical exercise. Half of the participants (n = 93) took part in a one‐month learning and training session using different behavioural modification techniques and conducted in a full‐board wellness centre (intense intervention group). The other half (n = 93) was randomized a one‐hour counselling session with a specially trained nurse (usual care group). Follow‐up was carried out after 12 months.
Main outcome measures. Body weight, oxygen consumption, plasminogen activator inhibitor type 1 (PAI‐1) activity, tissue plasminogen activator (tPA) antigen, fibrinogen and fasting plasma insulin measured at the start of the programme and at follow‐up after 1 year.
Results. The intense intervention group had a mean weight decline by 1 year of 5.4 kg compared to 0.5 kg in the usual care group. Oxygen consumption in the intense group increased 10% vs. a 1% decline in the usual care group. In the intense group, PAI‐1 activity decreased 31% (– 10.1 U mL–1), which was significantly more than in the usual care group (12%; – 3.0 U mL–1). The corresponding reductions in tPA antigen were 14% (– 1.65 μg L–1) and 6% (– 0.69 μg L–1).
Conclusions. The present randomized study shows that an intense lifestyle programme has sustained beneficial effects on fibrinolysis. |
| doi_str_mv | 10.1046/j.1365-2796.1999.00537.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69964124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69964124</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4717-852b8c8e046bd51e5b3633f011c8a0e1dfad93e863dfe7cc6e6d1100c345c7533</originalsourceid><addsrcrecordid>eNqNkdFv1SAYxYlxcXfTf8EQY3xrB6VQePBhWaa7Zste9JlQ-lVpaHuFdnf1r5fu3qjxaU8Qvt85cDgIYUpySkpx0eWUCZ4VlRI5VUrlhHBW5Y8v0ObP4CXaEMXLTMiCnKKzGDtCKCOCvEKnyaSsClZs0H7b78L4AA1uXR3cMPoluojrBbthgiEC9q6FOC0enk7CAwyTG4ccX-Jghmbs3a8knoIzPgE4znUHdop476Yf2PU740Kaf_ezHZPZNHpIMguv0UlrfIQ3x_Ucfft0_fXqJru9_7y9urzNbFnRKpO8qKWVkELXDafAayYYawmlVhoCtGlNoxhIwZoWKmsFiIZSQiwrua04Y-fow8E3pfw5pyC6d9GC92aAcY5aKCVKWpQJfPcf2I1zGNLbNFWVolyqFZIHyIYxxgCt3gXXm7BoSvTajO70WoBeC9BrM_qpGf2YpG-P_nPdQ_OP8FBFAt4fAROt8e36TS7-5aQkhKiEfTxge-dhefb9-sv99i7t2G_gmquY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>197915894</pqid></control><display><type>article</type><title>Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance</title><source>Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list)</source><creator>Lindahl, B. ; Nilsson, T. K. ; Jansson, J.‐H. ; Asplund, K. ; Hallmans, G.</creator><creatorcontrib>Lindahl, B. ; Nilsson, T. K. ; Jansson, J.‐H. ; Asplund, K. ; Hallmans, G.</creatorcontrib><description>Objective. To assess the effects of lifestyle intervention on cardiovascular risk factors in general and especially on fibrinolysis.
Design. Randomized clinical study.
Subjects. A total of 186 subjects with impaired glucose tolerance and obesity.
Interventions. The intervention programme included a low‐fat, high‐fibre diet and regular physical exercise. Half of the participants (n = 93) took part in a one‐month learning and training session using different behavioural modification techniques and conducted in a full‐board wellness centre (intense intervention group). The other half (n = 93) was randomized a one‐hour counselling session with a specially trained nurse (usual care group). Follow‐up was carried out after 12 months.
Main outcome measures. Body weight, oxygen consumption, plasminogen activator inhibitor type 1 (PAI‐1) activity, tissue plasminogen activator (tPA) antigen, fibrinogen and fasting plasma insulin measured at the start of the programme and at follow‐up after 1 year.
Results. The intense intervention group had a mean weight decline by 1 year of 5.4 kg compared to 0.5 kg in the usual care group. Oxygen consumption in the intense group increased 10% vs. a 1% decline in the usual care group. In the intense group, PAI‐1 activity decreased 31% (– 10.1 U mL–1), which was significantly more than in the usual care group (12%; – 3.0 U mL–1). The corresponding reductions in tPA antigen were 14% (– 1.65 μg L–1) and 6% (– 0.69 μg L–1).
Conclusions. The present randomized study shows that an intense lifestyle programme has sustained beneficial effects on fibrinolysis.</description><identifier>ISSN: 0954-6820</identifier><identifier>EISSN: 1365-2796</identifier><identifier>DOI: 10.1046/j.1365-2796.1999.00537.x</identifier><identifier>PMID: 10447232</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Antigens - blood ; Atherosclerosis (general aspects, experimental research) ; Behavior Therapy ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Glucose - metabolism ; Body Weight ; Cardiology. Vascular system ; Dietary Fats - administration & dosage ; Dietary Fiber - administration & dosage ; Exercise ; Female ; Fibrinogen - metabolism ; Fibrinolysis ; Glucose Tolerance Test ; Humans ; Insulin - blood ; insulin resistance ; intervention ; Life Style ; Male ; Medical sciences ; Middle Aged ; nonpharmacologic ; Oxygen Consumption ; Patient Education as Topic ; plasminogen activator inhibitor ; Plasminogen Activator Inhibitor 1 - metabolism ; Tissue Plasminogen Activator - immunology</subject><ispartof>Journal of internal medicine, 1999-07, Vol.246 (1), p.105-112</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Jul 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4717-852b8c8e046bd51e5b3633f011c8a0e1dfad93e863dfe7cc6e6d1100c345c7533</citedby><cites>FETCH-LOGICAL-c4717-852b8c8e046bd51e5b3633f011c8a0e1dfad93e863dfe7cc6e6d1100c345c7533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1880009$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10447232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindahl, B.</creatorcontrib><creatorcontrib>Nilsson, T. K.</creatorcontrib><creatorcontrib>Jansson, J.‐H.</creatorcontrib><creatorcontrib>Asplund, K.</creatorcontrib><creatorcontrib>Hallmans, G.</creatorcontrib><title>Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance</title><title>Journal of internal medicine</title><addtitle>J Intern Med</addtitle><description>Objective. To assess the effects of lifestyle intervention on cardiovascular risk factors in general and especially on fibrinolysis.
Design. Randomized clinical study.
Subjects. A total of 186 subjects with impaired glucose tolerance and obesity.
Interventions. The intervention programme included a low‐fat, high‐fibre diet and regular physical exercise. Half of the participants (n = 93) took part in a one‐month learning and training session using different behavioural modification techniques and conducted in a full‐board wellness centre (intense intervention group). The other half (n = 93) was randomized a one‐hour counselling session with a specially trained nurse (usual care group). Follow‐up was carried out after 12 months.
Main outcome measures. Body weight, oxygen consumption, plasminogen activator inhibitor type 1 (PAI‐1) activity, tissue plasminogen activator (tPA) antigen, fibrinogen and fasting plasma insulin measured at the start of the programme and at follow‐up after 1 year.
Results. The intense intervention group had a mean weight decline by 1 year of 5.4 kg compared to 0.5 kg in the usual care group. Oxygen consumption in the intense group increased 10% vs. a 1% decline in the usual care group. In the intense group, PAI‐1 activity decreased 31% (– 10.1 U mL–1), which was significantly more than in the usual care group (12%; – 3.0 U mL–1). The corresponding reductions in tPA antigen were 14% (– 1.65 μg L–1) and 6% (– 0.69 μg L–1).
Conclusions. The present randomized study shows that an intense lifestyle programme has sustained beneficial effects on fibrinolysis.</description><subject>Adult</subject><subject>Antigens - blood</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Behavior Therapy</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Glucose - metabolism</subject><subject>Body Weight</subject><subject>Cardiology. Vascular system</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fiber - administration & dosage</subject><subject>Exercise</subject><subject>Female</subject><subject>Fibrinogen - metabolism</subject><subject>Fibrinolysis</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>insulin resistance</subject><subject>intervention</subject><subject>Life Style</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>nonpharmacologic</subject><subject>Oxygen Consumption</subject><subject>Patient Education as Topic</subject><subject>plasminogen activator inhibitor</subject><subject>Plasminogen Activator Inhibitor 1 - metabolism</subject><subject>Tissue Plasminogen Activator - immunology</subject><issn>0954-6820</issn><issn>1365-2796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqNkdFv1SAYxYlxcXfTf8EQY3xrB6VQePBhWaa7Zste9JlQ-lVpaHuFdnf1r5fu3qjxaU8Qvt85cDgIYUpySkpx0eWUCZ4VlRI5VUrlhHBW5Y8v0ObP4CXaEMXLTMiCnKKzGDtCKCOCvEKnyaSsClZs0H7b78L4AA1uXR3cMPoluojrBbthgiEC9q6FOC0enk7CAwyTG4ccX-Jghmbs3a8knoIzPgE4znUHdop476Yf2PU740Kaf_ezHZPZNHpIMguv0UlrfIQ3x_Ucfft0_fXqJru9_7y9urzNbFnRKpO8qKWVkELXDafAayYYawmlVhoCtGlNoxhIwZoWKmsFiIZSQiwrua04Y-fow8E3pfw5pyC6d9GC92aAcY5aKCVKWpQJfPcf2I1zGNLbNFWVolyqFZIHyIYxxgCt3gXXm7BoSvTajO70WoBeC9BrM_qpGf2YpG-P_nPdQ_OP8FBFAt4fAROt8e36TS7-5aQkhKiEfTxge-dhefb9-sv99i7t2G_gmquY</recordid><startdate>199907</startdate><enddate>199907</enddate><creator>Lindahl, B.</creator><creator>Nilsson, T. K.</creator><creator>Jansson, J.‐H.</creator><creator>Asplund, K.</creator><creator>Hallmans, G.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199907</creationdate><title>Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance</title><author>Lindahl, B. ; Nilsson, T. K. ; Jansson, J.‐H. ; Asplund, K. ; Hallmans, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4717-852b8c8e046bd51e5b3633f011c8a0e1dfad93e863dfe7cc6e6d1100c345c7533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Antigens - blood</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Behavior Therapy</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Glucose - metabolism</topic><topic>Body Weight</topic><topic>Cardiology. Vascular system</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fiber - administration & dosage</topic><topic>Exercise</topic><topic>Female</topic><topic>Fibrinogen - metabolism</topic><topic>Fibrinolysis</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>insulin resistance</topic><topic>intervention</topic><topic>Life Style</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>nonpharmacologic</topic><topic>Oxygen Consumption</topic><topic>Patient Education as Topic</topic><topic>plasminogen activator inhibitor</topic><topic>Plasminogen Activator Inhibitor 1 - metabolism</topic><topic>Tissue Plasminogen Activator - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lindahl, B.</creatorcontrib><creatorcontrib>Nilsson, T. K.</creatorcontrib><creatorcontrib>Jansson, J.‐H.</creatorcontrib><creatorcontrib>Asplund, K.</creatorcontrib><creatorcontrib>Hallmans, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindahl, B.</au><au>Nilsson, T. K.</au><au>Jansson, J.‐H.</au><au>Asplund, K.</au><au>Hallmans, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance</atitle><jtitle>Journal of internal medicine</jtitle><addtitle>J Intern Med</addtitle><date>1999-07</date><risdate>1999</risdate><volume>246</volume><issue>1</issue><spage>105</spage><epage>112</epage><pages>105-112</pages><issn>0954-6820</issn><eissn>1365-2796</eissn><abstract>Objective. To assess the effects of lifestyle intervention on cardiovascular risk factors in general and especially on fibrinolysis.
Design. Randomized clinical study.
Subjects. A total of 186 subjects with impaired glucose tolerance and obesity.
Interventions. The intervention programme included a low‐fat, high‐fibre diet and regular physical exercise. Half of the participants (n = 93) took part in a one‐month learning and training session using different behavioural modification techniques and conducted in a full‐board wellness centre (intense intervention group). The other half (n = 93) was randomized a one‐hour counselling session with a specially trained nurse (usual care group). Follow‐up was carried out after 12 months.
Main outcome measures. Body weight, oxygen consumption, plasminogen activator inhibitor type 1 (PAI‐1) activity, tissue plasminogen activator (tPA) antigen, fibrinogen and fasting plasma insulin measured at the start of the programme and at follow‐up after 1 year.
Results. The intense intervention group had a mean weight decline by 1 year of 5.4 kg compared to 0.5 kg in the usual care group. Oxygen consumption in the intense group increased 10% vs. a 1% decline in the usual care group. In the intense group, PAI‐1 activity decreased 31% (– 10.1 U mL–1), which was significantly more than in the usual care group (12%; – 3.0 U mL–1). The corresponding reductions in tPA antigen were 14% (– 1.65 μg L–1) and 6% (– 0.69 μg L–1).
Conclusions. The present randomized study shows that an intense lifestyle programme has sustained beneficial effects on fibrinolysis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>10447232</pmid><doi>10.1046/j.1365-2796.1999.00537.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of internal medicine, 1999-07, Vol.246 (1), p.105-112 |
| issn | 0954-6820 1365-2796 |
| language | eng |
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| source | Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list) |
| subjects | Adult Antigens - blood Atherosclerosis (general aspects, experimental research) Behavior Therapy Biological and medical sciences Blood and lymphatic vessels Blood Glucose - metabolism Body Weight Cardiology. Vascular system Dietary Fats - administration & dosage Dietary Fiber - administration & dosage Exercise Female Fibrinogen - metabolism Fibrinolysis Glucose Tolerance Test Humans Insulin - blood insulin resistance intervention Life Style Male Medical sciences Middle Aged nonpharmacologic Oxygen Consumption Patient Education as Topic plasminogen activator inhibitor Plasminogen Activator Inhibitor 1 - metabolism Tissue Plasminogen Activator - immunology |
| title | Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance |
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