Filtration of diaspirin crosslinked hemoglobin into lung and soft tissue lymph

Diaspirin crosslinked hemoglobin (DCHb) is a new blood substitute manufactured from human blood. To evaluate its microvascular filtration properties, we infused DCLHb into unanesthetized sheep (10%, 20 ml/kg) and measured the flow and composition of lung and soft tissue lymph. For comparison, we als...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 1998-10, Vol.158 (4), p.1204-1212
Main Authors: CONHAIM, R. L, COOLER, S. D, MCGRATH, A. M, DEANGELES, D. A, MYERS, G. A, HARMS, B. A
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Aspirin - administration & dosage
Aspirin - analogs & derivatives
Aspirin - chemistry
Aspirin - pharmacokinetics
Biological and medical sciences
Blood Pressure - drug effects
Blood Substitutes - administration & dosage
Blood Substitutes - chemistry
Blood Substitutes - pharmacokinetics
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Evaluation Studies as Topic
Half-Life
Hematocrit
Hemoglobins - administration & dosage
Hemoglobins - chemistry
Hemoglobins - pharmacokinetics
Humans
Hydrostatic Pressure
Lung - metabolism
Lymph - metabolism
Lymph - secretion
Medical sciences
Microcirculation - metabolism
Osmotic Pressure
Pulmonary Artery
Pulmonary Wedge Pressure - drug effects
Serum Albumin - administration & dosage
Serum Albumin - chemistry
Serum Albumin - pharmacokinetics
Sheep
Tissue Distribution
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Summary:Diaspirin crosslinked hemoglobin (DCHb) is a new blood substitute manufactured from human blood. To evaluate its microvascular filtration properties, we infused DCLHb into unanesthetized sheep (10%, 20 ml/kg) and measured the flow and composition of lung and soft tissue lymph. For comparison, we also infused human serum albumin (HSA; 10%, 20 ml/kg). DCLHb raised systemic and pulmonary arterial pressures from baseline values of 83 +/- 7 and 13 +/- 2 mm Hg, respectively, to peak values of 113 +/- 9 and 26 +/- 3 mm Hg (p < 0.05 versus baseline). These increases were significantly greater than those associated with HSA, which raised systemic and pulmonary arterial pressures from baseline values of 86 +/- 4 and 13 +/- 2 mm Hg, respectively, to peak values of 97 +/- 3 and 21 +/- 7 mm Hg (p
ISSN:1073-449X
1535-4970
DOI:10.1164/ajrccm.158.4.9705042