Invasive Pulmonary Aspergillosis in a Critically Ill Neonate: Case Report and Review of Invasive Aspergillosis During the First 3 Months of Life

We report a fatal case of invasive pulmonary aspergillosis in a severely ill neonate and review 43 additional cases of invasive aspergillosis reported from 1955 through 1996 that occurred during the first 3 months of life. Eleven of the 44 patients had primary cutaneous aspergillosis, 10 had invasiv...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases 1998-09, Vol.27 (3), p.437-452
Main Authors: Groll, Andreas H., Jaeger, Gudrun, Allendorf, Antje, Herrmann, Guenter, Schloesser, Rolf, von Loewenich, Volker
Format: Article
Language:English
Subjects:
Amphotericin B - therapeutic use
Antifungal Agents - therapeutic use
Aspergillosis
Aspergillosis - drug therapy
Aspergillosis - epidemiology
Aspergillosis - physiopathology
Aspergillosis - transmission
Aspergillus
Aspergillus - isolation & purification
Autopsies
Central Nervous System Diseases - etiology
Chronic granulomatous disease
Clinical Articles
Critical Illness
Cross Infection - microbiology
Dermatomycoses - etiology
Dosage
Fatal Outcome
Fungal infections
Gastrointestinal Diseases - etiology
Humans
Infant
Infant, Newborn
Infants
Infections
Lesions
Lung Diseases - drug therapy
Lung Diseases - microbiology
Lung Diseases - physiopathology
Lungs
Male
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report a fatal case of invasive pulmonary aspergillosis in a severely ill neonate and review 43 additional cases of invasive aspergillosis reported from 1955 through 1996 that occurred during the first 3 months of life. Eleven of the 44 patients had primary cutaneous aspergillosis, 10 had invasive pulmonary aspergillosis, and 14 had disseminated disease. Most infections were nosocomial in origin. Prematurity (43%); proven chronic granulomatous disease (14%); and a complex of diarrhea, dehydration, malnutrition, and invasive bacterial infections (23%) accounted for the majority of underlying conditions. At least 41% of the patients had received corticosteroid therapy before diagnosis, but only one patient had been neutropenic. Among patients who received medical and/or surgical treatment, outcome was relatively favorable, with an overall survival rate of 73%. Invasive aspergillosis may occur in neonates and young infants and warrants consideration under certain circumstances. Current therapeutic approaches consist of high-dose amphotericin B and appropriate surgical interventions.
ISSN:1058-4838
1537-6591
DOI:10.1086/514717